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Literature summary extracted from

  • Lee, J.J.; Fasco, M.J.
    Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide (1984), Biochemistry, 23, 2246-2252.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.4.4 1,2-Ethanedithiol activation Rattus norvegicus
1.17.4.4 1,4-Butanedithiol activation Rattus norvegicus
1.17.4.4 dithioerythritol equally effective as DTT Rattus norvegicus
1.17.4.4 dithiothreitol DL-DTT and L-DTT equally effective Rattus norvegicus
1.17.4.4 lipoic acid
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 additional information not inhibited by iodoacetic acid Rattus norvegicus
1.17.4.4 N-ethylmaleimide inhibition increased if the enzyme is prereduced by DTT, 1,4-butanedithiol or 1,2-ethanediol Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 microsome integral membrane protein Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol Rattus norvegicus reaction in metabolic pathway of vitamin K vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol Rattus norvegicus Wistar reaction in metabolic pathway of vitamin K vitamin K + oxidized dithiothreitol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Rattus norvegicus
-
 Wistar strain
-
1.17.4.4 Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol 2-mercaptoethanol, reduced glutathione, cysteine and 1,6-hexanedithiol are inactive as acceptors Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol reaction in metabolic pathway of vitamin K Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol 2-mercaptoethanol, reduced glutathione, cysteine and 1,6-hexanedithiol are inactive as acceptors Rattus norvegicus Wistar vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol reaction in metabolic pathway of vitamin K Rattus norvegicus Wistar vitamin K + oxidized dithiothreitol
-
 ?