EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.88 | medicine | target enzyme for chemotherapy of hypercholesterolemias | Pseudomonas mevalonii |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.1.1.88 | wild-type and mutants, H381A, H381N, H381K, H381Q, 3 A resolution | Pseudomonas mevalonii |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.88 | H381K | - |
Pseudomonas mevalonii |
1.1.1.88 | H381N | - |
Pseudomonas mevalonii |
1.1.1.88 | H381Q | - |
Pseudomonas mevalonii |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.88 | 45540 | - |
amino acid composition | Pseudomonas mevalonii |
1.1.1.88 | 270100 | - |
sedimentation equilibrium centrifugation | Pseudomonas mevalonii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.88 | (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | Pseudomonas mevalonii | - |
(R)-mevalonate + NAD+ + CoA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.88 | Pseudomonas mevalonii | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.88 | (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | reaction mechanism purposal | Pseudomonas mevalonii |
EC Number | Storage Stability | Organism |
---|---|---|
1.1.1.88 | -180°C, 400 mM KCl, 24 months | Pseudomonas mevalonii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.88 | (R)-mevalonate + CoA + 2 NAD+ | - |
Pseudomonas mevalonii | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
? | |
1.1.1.88 | (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | - |
Pseudomonas mevalonii | (R)-mevalonate + NAD+ + CoA | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.88 | hexamer | 3alpha2, XSA | Pseudomonas mevalonii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.88 | NAD+ | - |
Pseudomonas mevalonii | |
1.1.1.88 | NADH | reverse reaction | Pseudomonas mevalonii |