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Literature summary extracted from

  • Turner, J.M.; Willetts, A.J.
    Amino ketone formation and aminopropanol-dehydrogenase activity in rat-liver preparations (1967), Biochem. J., 102, 511-519.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
1.1.1.75 stable on freezing and thawing an ultrasonication Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.75 2-mercaptoethanol
-
 Rattus norvegicus
1.1.1.75 D,L-3-hydroxybutyrate non-competitive, Ki: 200 mM in liver homogenates, little effect in soluble fraction from disintegrated mitochondria Rattus norvegicus
1.1.1.75 EDTA weak inhibition at high concentration, little effect in soluble extract of disintegrated mitochondria Rattus norvegicus
1.1.1.75 L-cysteine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.75 15
-
 1-aminopropan-2-ol liver homogenates Rattus norvegicus
1.1.1.75 200
-
 D,L-4-amino-3-hydroxybutyrate liver homogenates Rattus norvegicus
1.1.1.75 200
-
 1-aminopropan-2-ol soluble extract of disintegrated mitochondria Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.75 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.75 K+ inhibitory at all concentrations Rattus norvegicus
1.1.1.75 Mg2+ slightly activating at 1.3 mM, inhibitory above 3 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.75 L-1-aminopropan-2-ol + NAD+ Rattus norvegicus possible role in carnitine metabolism aminoacetone + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.75 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.75 heart
-
 Rattus norvegicus
-
1.1.1.75 kidney
-
 Rattus norvegicus
-
1.1.1.75 liver
-
 Rattus norvegicus
-
1.1.1.75 muscle
-
 Rattus norvegicus
-
1.1.1.75 spleen
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.75 0.001
-
 soluble extract of disintegrated mitochondria Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.75 D,L-1-aminopropan-2-ol + NAD+
-
 Rattus norvegicus aminoacetone + NADH
-
 ?
1.1.1.75 D,L-4-amino-3-hydroxybutyrate + NAD+
-
 Rattus norvegicus 4-amino-3-oxobutyrate + NADH
-
 ?
1.1.1.75 L-1-aminopropan-2-ol + NAD+
-
 Rattus norvegicus aminoacetone + NADH
-
 ?
1.1.1.75 L-1-aminopropan-2-ol + NAD+ possible role in carnitine metabolism Rattus norvegicus aminoacetone + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.75 9.1
-
 soluble extract of disintegrated mitochondria Rattus norvegicus
1.1.1.75 9.8
-
 liver homogenates Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.75 7.5 11 very low activity at pH 7.5, 60% of activity at pH 11 in liver homogenates Rattus norvegicus
1.1.1.75 8.5 10.5 40% of activity in soluble extract of disintegrated mitochondria Rattus norvegicus