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Literature summary extracted from
- On testicular 17beta-hydroxysteroid oxidoreductase product activation of testosterone formation from androstendione in vitro (1973), Biochim. Biophys. Acta, 306, 227-236.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.64 | testosterone | 0.023 mM, 2.6fold increase in androstenedione reduction | Homo sapiens |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.64 | 0.0015 | - |
testosterone | enzyme activity in cell-free homogenate, approximate value | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.64 | 17beta-estradiol + NADP+ | Homo sapiens | - |
estrone + NADPH | - |
r | |
| 1.1.1.64 | 17beta-estradiol + NADP+ | Oryctolagus cuniculus | - |
estrone + NADPH | - |
r | |
| 1.1.1.64 | testosterone + NADP+ | Homo sapiens | - |
androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
| 1.1.1.64 | testosterone + NADP+ | Oryctolagus cuniculus | - |
androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.64 | Homo sapiens | - |
- |
- |
| 1.1.1.64 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.64 | testis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.64 | 17beta-estradiol + NADP+ | - |
Homo sapiens | estrone + NADPH | - |
r | |
| 1.1.1.64 | 17beta-estradiol + NADP+ | - |
Oryctolagus cuniculus | estrone + NADPH | - |
r | |
| 1.1.1.64 | testosterone + NADP+ | - |
Homo sapiens | androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
| 1.1.1.64 | testosterone + NADP+ | - |
Oryctolagus cuniculus | androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.64 | 45 | - |
sharp drop of activity above | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.64 | 5.8 | - |
addition of testosterone shifts optimal pH to 7.4-7.8 | Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.64 | 4 | 9 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.64 | NADP+ | - |
Homo sapiens | |
| 1.1.1.64 | NADP+ | - |
Oryctolagus cuniculus | |
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