Literature summary extracted from

Inano, H.; Tamaoki, B.
Purificatition and properties of NADP-dependent 17beta-hydroxysteoid dehydrogenase solubilized from porcine-testicular microsomal fraction (1974), Eur. J. Biochem., 44, 13-23.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.64	testosterone	1 mM, 62.8% inhibition of androstendione reduction	Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.64	17beta-estradiol + NADP+	Sus scrofa	-	estrone + NADPH	-	r
1.1.1.64	testosterone + NADP+	Sus scrofa	-	androst-4-ene-3,17-dione + NADPH + H+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.64	Sus scrofa	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.64	-	Sus scrofa

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.64	testis	-	Sus scrofa	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.1.1.64	67.7	-	-	Sus scrofa

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.64	17beta-estradiol + NADP+	-	Sus scrofa	estrone + NADPH	-	r
1.1.1.64	testosterone + NADP+	-	Sus scrofa	androst-4-ene-3,17-dione + NADPH + H+	-	r
1.1.1.64	testosterone + NADP+	rate of oxidation is less than 30% of those for reduction	Sus scrofa	androst-4-ene-3,17-dione + NADPH + H+	-	r

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.64	NADP+	-	Sus scrofa

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Release 2023.1 (January 2023)