Literature summary extracted from

Andersson, S.; Geissler, W.M.; Wu, L.; Davis, D.L.; Grumbach, M.M.; New, M.I.; Schwarz, H.P.; Blethen, S.L.; Mendoca.B.B.; Bloise, W.; Witchel, S.F.; Cutler, G.B.; Griffin, J.E.; Wilson, J.D.; Russell, D.W.
Molecular genetics and pathophysiology of 17beta-hydroxysteroid dehydrogenase 3 deficiency (1996), J. Clin. Endocrinol., 81, 130-136.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.64	17beta-hydroxysteroid dehydrogenase 3, expressed in human embryonic kidney 293 cells	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.1.1.64	E215D	inactive enzyme	Homo sapiens
1.1.1.64	F208I	inactive enzyme	Homo sapiens
1.1.1.64	P282L	inactive enzyme	Homo sapiens
1.1.1.64	R80Q	20% residual activity	Homo sapiens
1.1.1.64	S65L	inactive enzyme	Homo sapiens
1.1.1.64	V205E	inactive enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.64	17beta-estradiol + NADP+	Homo sapiens	-	estrone + NADPH	-	r
1.1.1.64	testosterone + NADP+	Homo sapiens	-	androst-4-ene-3,17-dione + NADPH + H+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.64	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.64	17beta-estradiol + NADP+	-	Homo sapiens	estrone + NADPH	-	r
1.1.1.64	testosterone + NADP+	-	Homo sapiens	androst-4-ene-3,17-dione + NADPH + H+	-	r

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.64	NADP+	-	Homo sapiens

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Release 2023.1 (January 2023)