EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.62 | palm oil carotenoids | 0.001 mM, significant stimulation of the conversion of estradiol to estrone in the MCF-7 cell line | Homo sapiens | |
1.1.1.62 | retinoic acid | 0.001 mM, significant stimulation of the conversion of estradiol to estrone in the MCF-7 cell line and MDA-MB-231 cell line, 0.0001 mM has no effect | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.62 | palm oil carotenoids | 0.0001 mM, significant inhibition of the conversion of estradiol to estrone in the MCF-7 cell line | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.62 | estrone + NADH | Homo sapiens | the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer | estradiol-17beta + NAD+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.62 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.62 | estradiol-17beta + NAD+ | - |
Homo sapiens | estrone + NADH | - |
? | |
1.1.1.62 | estrone + NADH | the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer | Homo sapiens | estradiol-17beta + NAD+ | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.62 | NAD+ | cofactor | Homo sapiens |