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Literature summary extracted from

  • Blomquist, C.H.; Leung, B.S.; Zhang, R.; Zhu, Y.; Chang, P.M.
    Properties and regulation of 17beta-hydroxysteroid oxidoreductase of OVCAR-3, CAOV-3, and A431 cells: effects of epidermal growth factor, estradiol, and progesterone (1995), J. Cell. Biochem., 59, 409-417.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.62 cytosol type 1 enzyme Homo sapiens 5829
-
1.1.1.62 microsome type 2 enzyme Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.62 estrone + NADH Homo sapiens exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol estradiol-17beta + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 A-431 cell
-
 Homo sapiens
-
1.1.1.62 A-431 cell epidermoid tumor of the vulva, A431 Homo sapiens
-
1.1.1.62 breast cell line
-
 Homo sapiens
-
1.1.1.62 CAOV-3 cell enzyme type 2 from ovarian tumor: CAOV-3 Homo sapiens
-
1.1.1.62 MCF-7 cell
-
 Homo sapiens
-
1.1.1.62 MDA-MB-231 cell
-
 Homo sapiens
-
1.1.1.62 ovarian cancer cell enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3 and epidermoid tumor of the vulva, A431 Homo sapiens
-
1.1.1.62 ovary enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3 Homo sapiens
-
1.1.1.62 OVCAR-3 cell enzyme type 2 from ovarian tumor: OVCAR-3 Homo sapiens
-
1.1.1.62 T47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 estradiol-17beta + NAD+ type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens estrone + NADH
-
 ?
1.1.1.62 estrone + NADH exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol Homo sapiens estradiol-17beta + NAD+
-
 ?
1.1.1.62 estrone + NADPH + H+ type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens estradiol-17beta + NADP+
-
 ?
1.1.1.62 additional information type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 enzyme is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens ?
-
 ?
1.1.1.62 testosterone + NADP+
-
 Homo sapiens 4-androstene-3,17-dione + NADPH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NAD+ cofactor Homo sapiens