Literature summary extracted from

Mandrand-Berthelot, M.A.; Lagarde, A.E.
Hit-and-run mechanism for D-glucuronate reduction catalyzed by D-mannonate:NAD oxidoreductase of Escherichia coli (1977), Biochim. Biophys. Acta, 483, 6-23.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.57	ATP	competitive	Escherichia coli
1.1.1.57	D-altronate	non-competitive	Escherichia coli
1.1.1.57	D-mannonate	non-competitive	Escherichia coli
1.1.1.57	L-gulonate	mixed non-competitive	Escherichia coli
1.1.1.57	NAD+	competitive	Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.57	D-mannonate + NAD+	Escherichia coli	-	D-fructuronate + NADH	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.57	Escherichia coli	-	K 12	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.57	partial	Escherichia coli

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.1.1.57	0.008	-	crude extract	Escherichia coli
1.1.1.57	0.5	-	purified enzyme	Escherichia coli

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.57	D-glucuronate + NADH	-	Escherichia coli	L-gulonate + NAD+	-	?
1.1.1.57	D-mannonate + NAD+	-	Escherichia coli	D-fructuronate + NADH	-	r

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Release 2023.1 (January 2023)