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Literature summary extracted from

  • Szymanski, E.S.; Furfine, C.S.
    20beta-Hydroxysteroid oxidoreductase. Kinetics and binding of corticosteroids and corticosteroid-21-aldehydes (1977), J. Biol. Chem., 252, 205-211.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.53 20beta-Hydroxycortisol
-
 Streptomyces exfoliatus
1.1.1.53 20beta-hydroxyprogesterone
-
 Streptomyces exfoliatus
1.1.1.53 additional information substrate and product inhibition Streptomyces exfoliatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.53 additional information
-
 additional information
-
 Streptomyces exfoliatus
1.1.1.53 0.029
-
 NADH
-
 Streptomyces exfoliatus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.53 Streptomyces exfoliatus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.53 commercial preparation
-
 Streptomyces exfoliatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.53 cortisone + NAD(P)H i.e. 17beta,21-dihydroxy-pregn-4-ene-3,11,20-trione Streptomyces exfoliatus 17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
-
 ?