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Literature summary extracted from

  • Monder, C.
    Reduction of steroidal 20-oxo-21-oic acids to steroidal 20-beta-hydroxy-21-oic acids by 20beta-hydroxysteroid dehydrogenase (1978), J. Steroid Biochem., 9, 1229-1231.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.53 0.0061
-
 progesterone
-
 Streptomyces exfoliatus
1.1.1.53 0.14
-
 3,20-Dioxo-4-pregnen-21-oic acid
-
 Streptomyces exfoliatus
1.1.1.53 0.49
-
 17-Hydroxy-3,11,20-trioxo-4-pregnen-21-oate
-
 Streptomyces exfoliatus
1.1.1.53 0.64
-
 17-Hydroxy-3,20-dioxo-4-pregnen-21-oate
-
 Streptomyces exfoliatus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.53 Streptomyces exfoliatus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.53 commercial preparation
-
 Streptomyces exfoliatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.53 17-hydroxy-3,11,20-trioxo-4-pregnen-21-oate + NADH
-
 Streptomyces exfoliatus 17,20-dihydroxy-3,11-dioxo-4-pregnen-21-oate + NAD+
-
 ?
1.1.1.53 17-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
-
 Streptomyces exfoliatus 17,20-dihydroxy-4-pregnen-3-one-21-oate + NAD+
-
 ?
1.1.1.53 3,20-dioxo-4-pregnen-21-oic acid + NADH
-
 Streptomyces exfoliatus 20beta-hydroxy-3-oxo-4-pregnen-21-oic acid + NAD+
-
 ?
1.1.1.53 progesterone + NAD(P)H
-
 Streptomyces exfoliatus 20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.53 5.1
-
 reduction of oxo-steroids Streptomyces exfoliatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.53 NADH not NADPH Streptomyces exfoliatus
1.1.1.53 NADPH not Streptomyces exfoliatus