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Literature summary extracted from

  • Cho, S.W.; Joshi, J.G.
    Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain (1990), Neuroscience, 38, 819-828.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.49 ATP
-
 Homo sapiens
1.1.1.49 ATP
-
 Sus scrofa
1.1.1.49 EDTA slightly Homo sapiens
1.1.1.49 EDTA slightly Sus scrofa
1.1.1.49 NADP+
-
 Homo sapiens
1.1.1.49 NADPH
-
 Homo sapiens
1.1.1.49 NADPH
-
 Sus scrofa
1.1.1.49 palmitoyl-CoA leads to dissociation of active tetramers to inactive dimers Homo sapiens
1.1.1.49 palmitoyl-CoA leads to dissociation of active tetramers to inactive dimers Sus scrofa
1.1.1.49 Zn2+
-
 Homo sapiens
1.1.1.49 Zn2+
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.49 0.006 0.008 NADP+ isoenzymes I and II, with glucose 6-phosphate Homo sapiens
1.1.1.49 0.006 0.008 NADP+ isoenzymes I and II, with glucose 6-phosphate Sus scrofa
1.1.1.49 0.023
-
 NADPH isoenzyme II, with 6-phosphonogluconate 0.1 mM Sus scrofa
1.1.1.49 0.025
-
 NADP+ isoenzyme II, with 6-phosphonogluconate 0.1 mM Homo sapiens
1.1.1.49 0.031
-
 D-galactose 6-phosphate isoenzyme II Homo sapiens
1.1.1.49 0.046 0.047 D-galactose 6-phosphate isoenzyme I Homo sapiens
1.1.1.49 0.046 0.047 D-galactose 6-phosphate isoenzyme I Sus scrofa
1.1.1.49 0.051
-
 D-galactose 6-phosphate isoenzyme II Sus scrofa
1.1.1.49 0.056
-
 D-glucose 6-phosphate isoenzyme II Sus scrofa
1.1.1.49 0.061
-
 D-glucose 6-phosphate isoenzyme I Homo sapiens
1.1.1.49 0.167
-
 D-glucose 6-phosphate isoenzyme I Sus scrofa
1.1.1.49 0.18
-
 D-glucose 6-phosphate isoenzyme II Homo sapiens
1.1.1.49 0.279
-
 6-phosphonogluconate isoenzyme II Sus scrofa
1.1.1.49 0.864
-
 6-phosphonogluconate isoenzyme II Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.49 cytosol
-
 Homo sapiens 5829
-
1.1.1.49 cytosol
-
 Sus scrofa 5829
-
1.1.1.49 mitochondrion
-
 Homo sapiens 5739
-
1.1.1.49 mitochondrion
-
 Sus scrofa 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.49 Ca2+ activation Homo sapiens
1.1.1.49 Ca2+ activation Sus scrofa
1.1.1.49 Mg2+ activation Homo sapiens
1.1.1.49 Mg2+ activation Sus scrofa
1.1.1.49 additional information no metal ions necessary Homo sapiens
1.1.1.49 additional information no metal ions necessary Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.49 57000
-
 4 * 57000, SDS-PAGE Homo sapiens
1.1.1.49 57000
-
 4 * 57000, SDS-PAGE Sus scrofa
1.1.1.49 220000
-
 isoenzymes I and II, gel filtration Homo sapiens
1.1.1.49 220000
-
 isoenzymes I and II, gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ Homo sapiens
-
 D-gluconate 6-phosphate + NADPH + H+
-
 ?
1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ Sus scrofa
-
 D-gluconate 6-phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.49 Homo sapiens
-
 2 isoenzymes
-
1.1.1.49 Sus scrofa
-
 2 isoenzymes
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.49 isoenzymes I and II Homo sapiens
1.1.1.49 isoenzymes I and II Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.49 brain
-
 Homo sapiens
-
1.1.1.49 brain
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.49 50
-
 purified isoenzyme I Sus scrofa
1.1.1.49 52
-
 purified isoenzyme II Homo sapiens
1.1.1.49 201
-
 purified isoenzyme II Sus scrofa
1.1.1.49 210
-
 purified isoenzyme I Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.49 6-phosphonogluconate + NADPH isoenzyme II Homo sapiens ?
-
 ?
1.1.1.49 6-phosphonogluconate + NADPH isoenzyme II Sus scrofa ?
-
 ?
1.1.1.49 D-galactose 6-phosphate + NAD(P)+
-
 Homo sapiens D-galactonate 6-phosphate + NADH
-
 ?
1.1.1.49 D-galactose 6-phosphate + NAD(P)+
-
 Sus scrofa D-galactonate 6-phosphate + NADH
-
 ?
1.1.1.49 D-glucose 6-phosphate + H2O + NADP+
-
 Homo sapiens D-gluconate 6-phosphate + NADPH + H+
-
 ?
1.1.1.49 D-glucose 6-phosphate + H2O + NADP+
-
 Sus scrofa D-gluconate 6-phosphate + NADPH + H+
-
 ?
1.1.1.49 additional information both isoenzymes show no activity with glucose and NAD+, isoenzyme I shows no activity with 6-phosphonogluconate Homo sapiens ?
-
 ?
1.1.1.49 additional information both isoenzymes show no activity with glucose and NAD+, isoenzyme I shows no activity with 6-phosphonogluconate Sus scrofa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.49 tetramer 4 * 57000, SDS-PAGE Homo sapiens
1.1.1.49 tetramer 4 * 57000, SDS-PAGE Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.49 NADP+ absolute specificity Homo sapiens
1.1.1.49 NADP+ absolute specificity Sus scrofa