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Literature summary extracted from

  • Ozer, N.; Aksoy, Y.; Ogus, I.H.
    Kinetic properties of human placental glucose-6-phosphate dehydrogenase (2001), Int. J. Biochem. Cell Biol., 33, 221-226.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.49 2,3-diphosphoglycerate
-
 Homo sapiens
1.1.1.49 NADP+ at concentrations above 0.3 mM Homo sapiens
1.1.1.49 NADPH NADPH binding is important for physiological regulation of pentose phosphate pathway Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.49 0.02
-
 NADP+ with D-glucose 6-phosphate or D-galactose 6-phosphate Homo sapiens
1.1.1.49 0.03
-
 NADP+ with 2-deoxyglucose 6-phosphate, KM decreases to 10 mM with increasing substrate concentration from 0.3 to 1.5 mM Homo sapiens
1.1.1.49 0.04
-
 D-glucose 6-phosphate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.49 Mg2+ activation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ Homo sapiens hyperbolic cofactor binding D-gluconate 6-phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.49 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.49 D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+ rapid equilibrium ordered bi bi kinetic Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.49 placenta
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.49 -10°C, 10 mM Tris-HCl, pH 7.4, 5 mM 2-mercaptoethanol, 2 mM EDTA, 40% glycerol (v/v), weeks Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.49 2-deoxy-D-glucose-6-phosphate + NADP+
-
 Homo sapiens 2-deoxy-D-gluconate 6-phosphate + NADPH
-
 ?
1.1.1.49 D-galactose 6-phosphate + NAD(P)+
-
 Homo sapiens D-galactonate 6-phosphate + NADH
-
 ?
1.1.1.49 D-glucose 6-phosphate + deamino-NADP+
-
 Homo sapiens ?
-
 ?
1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ hyperbolic cofactor binding Homo sapiens D-gluconate 6-phosphate + NADPH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.49 dimer
-
 Homo sapiens
1.1.1.49 More presence of SH-reagents, high enzyme and Mg2+ or Mn2+ concentrations, low pH and ionic strength favour oligomeric, active forms of the enzyme, while the opposite conditions favour inactive monomers Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.49 43
-
 2-deoxyglucose 6-phosphate
-
 Homo sapiens
1.1.1.49 98
-
 deamino-NADP+
-
 Homo sapiens
1.1.1.49 157
-
 D-galactose 6-phosphate
-
 Homo sapiens
1.1.1.49 571
-
 D-glucose 6-phosphate
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.49 deamino-NADP+
-
 Homo sapiens
1.1.1.49 NADP+ high preference for Homo sapiens