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Literature summary extracted from

  • Moritz, B.; Striegel, K.; de Graaf, A.A.; Sahm, H.
    Kinetic properties of the glucose-6-phosphate and 6-phosphogluconate dehydrogenases from Corynebacterium glutamicum and their application for predicting pentose phosphate pathway flux in vivo (2000), Eur. J. Biochem., 267, 3442-3452.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 ATP
-
 [Candida] boidinii
1.1.1.44 ATP
-
 Corynebacterium glutamicum
1.1.1.44 ATP
-
 Escherichia coli
1.1.1.44 ATP
-
 Ovis aries
1.1.1.44 D-erythrose 4-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-erythrose 4-phosphate
-
 Corynebacterium glutamicum
1.1.1.44 D-fructose 1,6-diphosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-fructose 1,6-diphosphate
-
 [Candida] boidinii
1.1.1.44 D-fructose 1,6-diphosphate
-
 Corynebacterium glutamicum
1.1.1.44 D-fructose 1,6-diphosphate
-
 Escherichia coli
1.1.1.44 D-fructose 1,6-diphosphate
-
 Gluconobacter oxydans
1.1.1.44 D-fructose 1,6-diphosphate
-
 Ovis aries
1.1.1.44 D-fructose 1,6-diphosphate
-
 Pseudomonas sp.
1.1.1.44 D-glyceraldehyde 3-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-glyceraldehyde 3-phosphate
-
 Corynebacterium glutamicum
1.1.1.44 D-ribulose 5-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-ribulose 5-phosphate
-
 [Candida] boidinii
1.1.1.44 D-ribulose 5-phosphate
-
 Corynebacterium glutamicum
1.1.1.44 NADPH
-
 [Brevibacterium] flavum
1.1.1.44 NADPH
-
 [Candida] boidinii
1.1.1.44 NADPH
-
 Corynebacterium glutamicum
1.1.1.44 NADPH
-
 Escherichia coli
1.1.1.44 oxaloacetate
-
 [Brevibacterium] flavum
1.1.1.44 oxaloacetate
-
 Corynebacterium glutamicum
1.1.1.44 oxaloacetate
-
 Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.017
-
 NADP+
-
 Corynebacterium glutamicum
1.1.1.44 0.034
-
 6-phosphogluconate
-
 Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Pseudomonas sp.
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ [Candida] boidinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Acer pseudoplatanus
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Gluconobacter oxydans
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Corynebacterium glutamicum ssp. flavum
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Escherichia coli enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Saccharomyces cerevisiae enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ [Brevibacterium] flavum enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Corynebacterium glutamicum enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Pseudomonas sp. C
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Acer pseudoplatanus
-
-
-
1.1.1.44 Corynebacterium glutamicum
-
 ATCC 13032
-
1.1.1.44 Corynebacterium glutamicum ssp. flavum
-
-
-
1.1.1.44 Escherichia coli
-
-
-
1.1.1.44 Gluconobacter oxydans
-
-
-
1.1.1.44 Ovis aries
-
-
-
1.1.1.44 Pseudomonas sp.
-
 C
-
1.1.1.44 Pseudomonas sp. C
-
 C
-
1.1.1.44 Saccharomyces cerevisiae
-
-
-
1.1.1.44 [Brevibacterium] flavum
-
-
-
1.1.1.44 [Candida] boidinii
-
 methanol utilizing yeast
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 [Candida] boidinii
1.1.1.44
-
 Corynebacterium glutamicum
1.1.1.44
-
 Acer pseudoplatanus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 72
-
-
 Corynebacterium glutamicum
1.1.1.44 143
-
-
 Corynebacterium glutamicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Escherichia coli D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Saccharomyces cerevisiae D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Pseudomonas sp. D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 [Candida] boidinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 [Brevibacterium] flavum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Corynebacterium glutamicum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Acer pseudoplatanus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Gluconobacter oxydans D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Corynebacterium glutamicum ssp. flavum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Escherichia coli D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Saccharomyces cerevisiae D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway [Brevibacterium] flavum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Corynebacterium glutamicum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Pseudomonas sp. C D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 additional information
-
 Ovis aries ?
-
 ?
1.1.1.44 additional information glucose-6-phosphate is no substrate Corynebacterium glutamicum ?
-
 ?