Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rippa, M.; Giovannini, P.P.; Barrett, M.P.; Dallocchio, F.; Hanau, S.
    6-Phosphogluconate dehydrogenase: The mechanism of action investigated by a comparison of the enzyme from different species (1998), Biochim. Biophys. Acta, 1429, 83-92.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.44 6-phosphogluconate bona fide allosteric activator Ovis aries

Application

EC Number Application Comment Organism
1.1.1.44 medicine
-
 Homo sapiens
1.1.1.44 medicine 6PGDH might be a target for chemotherapy against parasitic infections as trypanosomiasis Trypanosoma brucei

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.44 6PGDH cDNA encodes a protein with 94% sequence identity with the sheep liver enzyme Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.44
-
 Ovis aries
1.1.1.44
-
 Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 3-Oxo-2-deoxy-6-phosphogluconate competitive inhibitor Trypanosoma brucei
1.1.1.44 NADPH
-
 Homo sapiens
1.1.1.44 NADPH
-
 Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.0096
-
 2-deoxy-3-oxo-6-phosphogluconate
-
 Trypanosoma brucei
1.1.1.44 0.016
-
 6-phosphogluconate
-
 Ovis aries
1.1.1.44 0.023
-
 6-phosphogluconate
-
 Homo sapiens
1.1.1.44 0.035
-
 6-phosphogluconate
-
 Trypanosoma brucei
1.1.1.44 0.082
-
 2-deoxy-3-oxo-6-phosphogluconate
-
 Homo sapiens
1.1.1.44 1.42
-
 2-deoxy-3-oxo-6-phosphogluconate
-
 Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Trypanosoma brucei
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Cyberlindnera jadinii
-
-
-
1.1.1.44 Homo sapiens
-
 human
-
1.1.1.44 Ovis aries
-
 sheep
-
1.1.1.44 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Homo sapiens
1.1.1.44
-
 Ovis aries
1.1.1.44 purified from an overexpressing Escherichia coli strain Trypanosoma brucei

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 erythrocyte
-
 Homo sapiens
-
1.1.1.44 erythrocyte
-
 Ovis aries
-
1.1.1.44 heart
-
 Homo sapiens
-
1.1.1.44 liver
-
 Homo sapiens
-
1.1.1.44 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 2-deoxy-3-oxo 6-phosphogluconate + ?
-
 Homo sapiens ?
-
 ?
1.1.1.44 2-deoxy-3-oxo 6-phosphogluconate + ?
-
 Trypanosoma brucei ?
-
 ?
1.1.1.44 2-deoxy-3-oxo 6-phosphogluconate + ? no decarboxylation by the liver enzyme Ovis aries ?
-
 ?
1.1.1.44 2-deoxy-6-phosphogluconate + NADP+
-
 Cyberlindnera jadinii 2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
 r
1.1.1.44 2-deoxy-6-phosphogluconate + NADP+
-
 Ovis aries 2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Trypanosoma brucei D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.44 dimer
-
 Cyberlindnera jadinii
1.1.1.44 dimer
-
 Homo sapiens
1.1.1.44 dimer
-
 Ovis aries
1.1.1.44 dimer
-
 Trypanosoma brucei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 6.8 7.2 decarboxylation in absence of activators Homo sapiens
1.1.1.44 6.8 7.2 decarboxylation in absence of activators Trypanosoma brucei
1.1.1.44 8
-
-
 Cyberlindnera jadinii
1.1.1.44 8
-
 6-phosphogluconate oxidation Homo sapiens
1.1.1.44 8
-
 6-phosphogluconate oxidation Ovis aries
1.1.1.44 8
-
 6-phosphogluconate oxidation Trypanosoma brucei
1.1.1.44 9
-
 6-phosphogluconate-activated decarboxylation Trypanosoma brucei
1.1.1.44 9.1
-
 reduction Homo sapiens
1.1.1.44 9.1
-
 reduction Ovis aries
1.1.1.44 10
-
-
 Trypanosoma brucei