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Literature summary extracted from

  • Dallocchio, F.; Matteuzzi, M.; Bellini, T.
    Half-site reactivity in 6-phosphogluconate dehydrogenase from human erythrocytes (1985), Biochem. J., 227, 305-310.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 D-6-sulfogluconate
-
 Cyberlindnera jadinii
1.1.1.44 D-6-sulfogluconate
-
 Homo sapiens
1.1.1.44 NADPH competitive inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.02
-
 6-phosphogluconate
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.44 104000
-
-
 Ovis aries
1.1.1.44 104000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Cyberlindnera jadinii
-
-
-
1.1.1.44 Homo sapiens
-
 human
-
1.1.1.44 Ovis aries
-
 sheep
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 erythrocyte
-
 Homo sapiens
-
1.1.1.44 erythrocyte
-
 Ovis aries
-
1.1.1.44 liver
-
 Homo sapiens
-
1.1.1.44 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.44 dimer
-
 Cyberlindnera jadinii
1.1.1.44 dimer
-
 Homo sapiens
1.1.1.44 dimer
-
 Ovis aries