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Literature summary extracted from

  • Toews, M.L.; Kanji, M.I.; Carper, R.W.
    6-Phosphogluconate dehydrogenase. Purification and kinetics (1976), J. Biol. Chem., 251, 7127-7131.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.1.1.44 enzyme loses no activity on dialysis overnight against 10 mM EDTA Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 CO2
-
 Sus scrofa
1.1.1.44 Mg2+ acts as an inhibitor above 20 mM Sus scrofa
1.1.1.44 NADPH
-
 Homo sapiens
1.1.1.44 NADPH
-
 Rattus norvegicus
1.1.1.44 NADPH
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.0135
-
 6-phosphogluconate
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.44 cytoplasm
-
 Cyberlindnera jadinii 5737
-
1.1.1.44 cytoplasm
-
 Homo sapiens 5737
-
1.1.1.44 cytoplasm
-
 Rattus norvegicus 5737
-
1.1.1.44 cytoplasm
-
 Sus scrofa 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.44 Mg2+
-
 Cyberlindnera jadinii
1.1.1.44 Mg2+
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.44 83000
-
 gel filtration, method of Ornstein and Davis Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Rattus norvegicus
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Sus scrofa
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Cyberlindnera jadinii
-
-
-
1.1.1.44 Homo sapiens
-
 human
-
1.1.1.44 Ovis aries
-
 sheep
-
1.1.1.44 Rattus norvegicus
-
 rat
-
1.1.1.44 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Homo sapiens
1.1.1.44
-
 Rattus norvegicus
1.1.1.44
-
 Sus scrofa
1.1.1.44
-
 Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 erythrocyte
-
 Homo sapiens
-
1.1.1.44 erythrocyte
-
 Ovis aries
-
1.1.1.44 liver
-
 Homo sapiens
-
1.1.1.44 liver
-
 Rattus norvegicus
-
1.1.1.44 liver
-
 Sus scrofa
-
1.1.1.44 liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 0.41
-
-
 Sus scrofa
1.1.1.44 1.89
-
 supernatant fraction Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Sus scrofa D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 8.5
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.44 7.5 10
-
 Sus scrofa