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Literature summary extracted from
- Human 6-phosphogluconate dehydrogenase. Purification of the erythrocyte enzyme and the influence of ions and NADPH on its activity (1974), Eur. J. Biochem., 42, 213-223.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.1.1.44 | medicine | with a deficiency of 6-phosphogluconate dehydrogenase some reticulocytosis occurs | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.44 | D-fructose 1,6-diphosphate | - |
Ovis aries |  |
| 1.1.1.44 | NADPH | product inhibition | Homo sapiens | |
| 1.1.1.44 | phosphate | competitive inhibitor of the substrates | Homo sapiens | |
| 1.1.1.44 | phosphate | - |
Ovis aries | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.44 | 0.02 | - |
6-phosphogluconate | - |
Homo sapiens | |
| 1.1.1.44 | 0.03 | - |
NADP+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.44 | 6-phospho-D-gluconate + NADP+ | Homo sapiens | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 1.1.1.44 | 6-phospho-D-gluconate + NADP+ | Ovis aries | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.44 | Homo sapiens | - |
human | - |
| 1.1.1.44 | Ovis aries | - |
sheep | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.44 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.44 | erythrocyte | - |
Homo sapiens | - |
| 1.1.1.44 | erythrocyte | - |
Ovis aries | - |
| 1.1.1.44 | liver | - |
Homo sapiens | - |
| 1.1.1.44 | liver | - |
Ovis aries | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.44 | 10 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.44 | 6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 1.1.1.44 | 6-phospho-D-gluconate + NADP+ | - |
Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.44 | 8.3 | - |
- |
Homo sapiens |
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Release 2023.1 (January 2023)
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