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Literature summary extracted from

  • Rippa, M.; Signorini, M.; Dallocchio, F.
    A multiple role for the coenzyme in the mechanism of action of 6-phosphogluconate dehydrogenase (1973), J. Biol. Chem., 248, 4920-4925.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.44
-
 Cyberlindnera jadinii

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 D-2-deoxyglucose
-
 Cyberlindnera jadinii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.02
-
 NADP+
-
 Cyberlindnera jadinii
1.1.1.44 0.054
-
 6-phosphogluconate
-
 Cyberlindnera jadinii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Sus scrofa
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Saccharomyces cerevisiae
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Cyberlindnera jadinii
-
-
-
1.1.1.44 Saccharomyces cerevisiae
-
-
-
1.1.1.44 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Saccharomyces cerevisiae

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 2-deoxy-6-phosphogluconate + NADP+ oxidation, 1.5% activity of that of 6-phosphogluconate Cyberlindnera jadinii 3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
 r
1.1.1.44 3-oxo-2-deoxy-6-phosphogluconate + NADP+ decarboxylation Cyberlindnera jadinii 1-deoxyribulose 5-phosphate + CO2 + NADPH
-
 r
1.1.1.44 3-oxo-2-deoxy-6-phosphogluconate + NADPH reduction Cyberlindnera jadinii 2-deoxy-6-phosphogluconate + NADP+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Sus scrofa D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Saccharomyces cerevisiae D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r