BRENDA - Enzyme Database show

Sheep liver 6-phosphogluconate dehydrogenase. Inhibition by nucleoside phosphates and by other metabolic intermediates

Dyson, J.E.D.; D'Orazio, R.E.; J. Biol. Chem. 248, 5428-5435 (1973)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.44
2'-AMP
-
Ovis aries
1.1.1.44
3'-AMP
-
Ovis aries
1.1.1.44
adenosine
-
Ovis aries
1.1.1.44
ADP
-
Ovis aries
1.1.1.44
ATP
-
Ovis aries
1.1.1.44
CDP
-
Ovis aries
1.1.1.44
citrate
-
Ovis aries
1.1.1.44
CMP
-
Ovis aries
1.1.1.44
CTP
-
Ovis aries
1.1.1.44
D-fructose 1,6-diphosphate
-
Ovis aries
1.1.1.44
D-Fructose 1-phosphate
-
Ovis aries
1.1.1.44
D-fructose 6-phosphate
-
Ovis aries
1.1.1.44
D-glucose 6-phosphate
-
Ovis aries
1.1.1.44
diphosphate
-
Ovis aries
1.1.1.44
GDP
-
Ovis aries
1.1.1.44
GMP
-
Ovis aries
1.1.1.44
GTP
-
Ovis aries
1.1.1.44
IDP
-
Ovis aries
1.1.1.44
IMP
-
Ovis aries
1.1.1.44
ITP
-
Ovis aries
1.1.1.44
nicotinamide
-
Ovis aries
1.1.1.44
oxalate
-
Ovis aries
1.1.1.44
oxaloacetate
-
Ovis aries
1.1.1.44
phosphate
-
Ovis aries
1.1.1.44
sulfate
-
Ovis aries
1.1.1.44
TDP
-
Ovis aries
1.1.1.44
TMP
-
Ovis aries
1.1.1.44
TTP
-
Ovis aries
1.1.1.44
UDP
-
Ovis aries
1.1.1.44
UMP
-
Ovis aries
1.1.1.44
UTP
-
Ovis aries
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.44
0.007
-
NADP+
-
Ovis aries
1.1.1.44
0.016
-
6-phosphogluconate
-
Ovis aries
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.44
6-phospho-D-gluconate + NADP+
Ovis aries
enzyme specific for the oxidative pentose phosphate pathway
D-ribulose 5-phosphate + CO2 + NADPH
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.44
Ovis aries
-
sheep
-
Purification (Commentary)
EC Number
Commentary
Organism
1.1.1.44
-
Ovis aries
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.44
liver
-
Ovis aries
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.44
6-phospho-D-gluconate + NADP+
-
286830
Ovis aries
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
r
1.1.1.44
6-phospho-D-gluconate + NADP+
enzyme specific for the oxidative pentose phosphate pathway
286830
Ovis aries
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.44
NADP+
-
Ovis aries
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.44
NADP+
-
Ovis aries
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.44
2'-AMP
-
Ovis aries
1.1.1.44
3'-AMP
-
Ovis aries
1.1.1.44
adenosine
-
Ovis aries
1.1.1.44
ADP
-
Ovis aries
1.1.1.44
ATP
-
Ovis aries
1.1.1.44
CDP
-
Ovis aries
1.1.1.44
citrate
-
Ovis aries
1.1.1.44
CMP
-
Ovis aries
1.1.1.44
CTP
-
Ovis aries
1.1.1.44
D-fructose 1,6-diphosphate
-
Ovis aries
1.1.1.44
D-Fructose 1-phosphate
-
Ovis aries
1.1.1.44
D-fructose 6-phosphate
-
Ovis aries
1.1.1.44
D-glucose 6-phosphate
-
Ovis aries
1.1.1.44
diphosphate
-
Ovis aries
1.1.1.44
GDP
-
Ovis aries
1.1.1.44
GMP
-
Ovis aries
1.1.1.44
GTP
-
Ovis aries
1.1.1.44
IDP
-
Ovis aries
1.1.1.44
IMP
-
Ovis aries
1.1.1.44
ITP
-
Ovis aries
1.1.1.44
nicotinamide
-
Ovis aries
1.1.1.44
oxalate
-
Ovis aries
1.1.1.44
oxaloacetate
-
Ovis aries
1.1.1.44
phosphate
-
Ovis aries
1.1.1.44
sulfate
-
Ovis aries
1.1.1.44
TDP
-
Ovis aries
1.1.1.44
TMP
-
Ovis aries
1.1.1.44
TTP
-
Ovis aries
1.1.1.44
UDP
-
Ovis aries
1.1.1.44
UMP
-
Ovis aries
1.1.1.44
UTP
-
Ovis aries
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.44
0.007
-
NADP+
-
Ovis aries
1.1.1.44
0.016
-
6-phosphogluconate
-
Ovis aries
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.44
6-phospho-D-gluconate + NADP+
Ovis aries
enzyme specific for the oxidative pentose phosphate pathway
D-ribulose 5-phosphate + CO2 + NADPH
-
-
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.44
-
Ovis aries
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.44
liver
-
Ovis aries
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.44
6-phospho-D-gluconate + NADP+
-
286830
Ovis aries
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
r
1.1.1.44
6-phospho-D-gluconate + NADP+
enzyme specific for the oxidative pentose phosphate pathway
286830
Ovis aries
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
r