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Literature summary extracted from

  • Dyson, J.E.D.; D'Orazio, R.E.
    Sheep liver 6-phosphogluconate dehydrogenase. Inhibition by nucleoside phosphates and by other metabolic intermediates (1973), J. Biol. Chem., 248, 5428-5435.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 2'-AMP
-
 Ovis aries
1.1.1.44 3'-AMP
-
 Ovis aries
1.1.1.44 adenosine
-
 Ovis aries
1.1.1.44 ADP
-
 Ovis aries
1.1.1.44 ATP
-
 Ovis aries
1.1.1.44 CDP
-
 Ovis aries
1.1.1.44 citrate
-
 Ovis aries
1.1.1.44 CMP
-
 Ovis aries
1.1.1.44 CTP
-
 Ovis aries
1.1.1.44 D-fructose 1,6-diphosphate
-
 Ovis aries
1.1.1.44 D-Fructose 1-phosphate
-
 Ovis aries
1.1.1.44 D-fructose 6-phosphate
-
 Ovis aries
1.1.1.44 D-glucose 6-phosphate
-
 Ovis aries
1.1.1.44 diphosphate
-
 Ovis aries
1.1.1.44 GDP
-
 Ovis aries
1.1.1.44 GMP
-
 Ovis aries
1.1.1.44 GTP
-
 Ovis aries
1.1.1.44 IDP
-
 Ovis aries
1.1.1.44 IMP
-
 Ovis aries
1.1.1.44 ITP
-
 Ovis aries
1.1.1.44 nicotinamide
-
 Ovis aries
1.1.1.44 oxalate
-
 Ovis aries
1.1.1.44 oxaloacetate
-
 Ovis aries
1.1.1.44 phosphate
-
 Ovis aries
1.1.1.44 sulfate
-
 Ovis aries
1.1.1.44 TDP
-
 Ovis aries
1.1.1.44 TMP
-
 Ovis aries
1.1.1.44 TTP
-
 Ovis aries
1.1.1.44 UDP
-
 Ovis aries
1.1.1.44 UMP
-
 Ovis aries
1.1.1.44 UTP
-
 Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.007
-
 NADP+
-
 Ovis aries
1.1.1.44 0.016
-
 6-phosphogluconate
-
 Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Ovis aries
-
 sheep
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+
-
 Ovis aries