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Literature summary extracted from

  • Procsal, D.; Holten, D.
    Purification and properties of rat liver 6-phosphogluconate dehydrogenase. Activity at normal in vivo concentration (1972), Biochemistry, 11, 1310-1314.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 D-fructose 1,6-diphosphate
-
 Ovis aries
1.1.1.44 NADPH
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.013
-
 NADP+
-
 Rattus norvegicus
1.1.1.44 0.071
-
 6-phosphogluconate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.44 cytoplasm
-
 Rattus norvegicus 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.44 52000
-
 2 * 52000, SDS-PAGE Rattus norvegicus
1.1.1.44 102000
-
 gel filtration Rattus norvegicus
1.1.1.44 104000
-
-
 Ovis aries
1.1.1.44 129000
-
-
 Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Mus musculus
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Rattus norvegicus
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Rattus norvegicus Sprague-Dawley
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Mus musculus
-
 mouse
-
1.1.1.44 Ovis aries
-
 sheep
-
1.1.1.44 Rattus norvegicus
-
 rat
-
1.1.1.44 Rattus norvegicus
-
 Sprague-Dawley
-
1.1.1.44 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Rattus norvegicus
1.1.1.44
-
 Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 liver
-
 Mus musculus
-
1.1.1.44 liver
-
 Rattus norvegicus
-
1.1.1.44 liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 32
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.1.1.44 4°C, purified enzyme, stored in 20% glycerol is stable for months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Mus musculus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus Sprague-Dawley D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.44 dimer
-
 Ovis aries
1.1.1.44 dimer 2 * 52000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 8.3
-
 Tris-Cl orbicine-acetate buffers Rattus norvegicus