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Literature summary extracted from
- Structural basis for a change in substrate specificity: crystal structur of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NAPD (2001), Biochemistry, 40, 4234-4241.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.1.1.42 | S113E | Escherichia coli |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.1.1.42 | S113E | affinity for isopropylmalate is 37-fold compared to wild-type | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.42 | isocitrate + NADP+ | Escherichia coli | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.42 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.42 | isocitrate + NADP+ | - |
Escherichia coli | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
| 1.1.1.42 | isopropylmalate + NADP+ | - |
Escherichia coli | ? | - |
? | |
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Release 2023.1 (January 2023)
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