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Literature summary extracted from

  • Grissom, C.B.; Cleland, W.W.
    Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase (1988), Biochemistry, 27, 2934-2943.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 oxalylglycine
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.42 Cd2+ absolute requirement for divalent cations Sus scrofa
1.1.1.42 Mg2+ absolute requirement for divalent cations Sus scrofa
1.1.1.42 Mn2+ absolute requirement for divalent cations Sus scrofa
1.1.1.42 Ni2+ absolute requirement for divalent cations Sus scrofa
1.1.1.42 Zn2+ absolute requirement for divalent cations Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Sus scrofa
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Sus scrofa
-
 pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 3-fluoroisocitrate + NADP+
-
 Sus scrofa 3-fluoro-2-oxoglutarate + NADPH + CO2
-
 ?
1.1.1.42 3-hydroxyisocitrate + NADP+
-
 Sus scrofa 3-hydroxy-2-oxoglutarate + NADPH + CO2
-
 ?
1.1.1.42 isocitrate + NADP+
-
 Sus scrofa 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
 Sus scrofa