BRENDA - Enzyme Database

Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase

Grissom, C.B.; Cleland, W.W.; Biochemistry 27, 2934-2943 (1988)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
oxalylglycine
-
Sus scrofa
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.42
Cd2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Mg2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Mn2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Ni2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Zn2+
absolute requirement for divalent cations
Sus scrofa
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Sus scrofa
-
2-oxoglutarate + NADPH + CO2
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Sus scrofa
-
pig
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
heart
-
Sus scrofa
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
3-fluoroisocitrate + NADP+
-
286797
Sus scrofa
3-fluoro-2-oxoglutarate + NADPH + CO2
-
-
-
?
1.1.1.42
3-hydroxyisocitrate + NADP+
-
286797
Sus scrofa
3-hydroxy-2-oxoglutarate + NADPH + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
286797
Sus scrofa
2-oxoglutarate + NADPH + CO2
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Sus scrofa
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
oxalylglycine
-
Sus scrofa
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.42
Cd2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Mg2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Mn2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Ni2+
absolute requirement for divalent cations
Sus scrofa
1.1.1.42
Zn2+
absolute requirement for divalent cations
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Sus scrofa
-
2-oxoglutarate + NADPH + CO2
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
heart
-
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
3-fluoroisocitrate + NADP+
-
286797
Sus scrofa
3-fluoro-2-oxoglutarate + NADPH + CO2
-
-
-
?
1.1.1.42
3-hydroxyisocitrate + NADP+
-
286797
Sus scrofa
3-hydroxy-2-oxoglutarate + NADPH + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
286797
Sus scrofa
2-oxoglutarate + NADPH + CO2
-
-
-
-