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Literature summary extracted from

  • Meixner-Monori, B.; Kubicek, C.P.; Harrer, W.; Schreferl, G.; Rohe, M.
    NADP-specific isocitrate dehydrogenase from the citric acid-accumulating fungus Aspergillus niger (1986), Biochem. J., 236, 549-557.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 2-oxoglutarate substrate inhibition Aspergillus niger
1.1.1.42 ATP
-
 Aspergillus niger
1.1.1.42 citrate
-
 Aspergillus niger
1.1.1.42 glyoxylate plus oxaloacetate Aspergillus niger
1.1.1.42 NADPH
-
 Aspergillus niger

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.42 cytoplasm
-
 Aspergillus niger 5737
-
1.1.1.42 cytoplasm
-
 Phycomyces blakesleeanus 5737
-
1.1.1.42 cytoplasm
-
 Blastocladiella emersonii 5737
-
1.1.1.42 mitochondrion
-
 Aspergillus niger 5739
-
1.1.1.42 mitochondrion
-
 Phycomyces blakesleeanus 5739
-
1.1.1.42 mitochondrion
-
 Blastocladiella emersonii 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.42 Mg2+ absolute requirement for divalent cations Aspergillus niger
1.1.1.42 Mn2+ absolute requirement for divalent cations Aspergillus niger

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.42 60000
-
 PAGE Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Aspergillus niger
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+ Phycomyces blakesleeanus
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+ Blastocladiella emersonii
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Aspergillus niger
-
-
-
1.1.1.42 Blastocladiella emersonii
-
-
-
1.1.1.42 Phycomyces blakesleeanus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.42
-
 Aspergillus niger

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.42 14.4
-
-
 Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
 Aspergillus niger 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+
-
 Phycomyces blakesleeanus 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+
-
 Blastocladiella emersonii 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.42 28
-
-
 Aspergillus niger

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.42 6 8
-
 Aspergillus niger

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.42 6.3 7.8
-
 Aspergillus niger

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
 Aspergillus niger
1.1.1.42 NADP+
-
 Phycomyces blakesleeanus
1.1.1.42 NADP+
-
 Blastocladiella emersonii