BRENDA - Enzyme Database

Characterization of the physicochemical and catalytic properties of human heart NADP-dependent isocitrate dehydrogenase

Seelig, G.F.; Colman, R.F.; Arch. Biochem. Biophys. 188, 394-409 (1978)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
2',5'-ADP
-
Homo sapiens
1.1.1.42
2-oxoglutarate
substrate inhibition
Homo sapiens
1.1.1.42
5'-ADP
-
Homo sapiens
1.1.1.42
ATP
-
Homo sapiens
1.1.1.42
citrate
-
Homo sapiens
1.1.1.42
nicotinamide mononucleotide
-
Homo sapiens
1.1.1.42
propanetricarboxylate
-
Homo sapiens
1.1.1.42
Threo-L-Isocitrate
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.42
0.0022
-
D,L-isocitrate
-
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.1.1.42
53000
-
gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Escherichia coli
-
2-oxoglutarate + NADPH + CO2
-
-
?
1.1.1.42
isocitrate + NADP+
Homo sapiens
-
2-oxoglutarate + NADPH + CO2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Escherichia coli
-
-
-
1.1.1.42
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.1.1.42
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
heart
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
286786
Escherichia coli
2-oxoglutarate + NADPH + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
286786
Homo sapiens
2-oxoglutarate + NADPH + CO2
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
2',5'-ADP
-
Homo sapiens
1.1.1.42
2-oxoglutarate
substrate inhibition
Homo sapiens
1.1.1.42
5'-ADP
-
Homo sapiens
1.1.1.42
ATP
-
Homo sapiens
1.1.1.42
citrate
-
Homo sapiens
1.1.1.42
nicotinamide mononucleotide
-
Homo sapiens
1.1.1.42
propanetricarboxylate
-
Homo sapiens
1.1.1.42
Threo-L-Isocitrate
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.42
0.0022
-
D,L-isocitrate
-
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.1.1.42
53000
-
gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Escherichia coli
-
2-oxoglutarate + NADPH + CO2
-
-
?
1.1.1.42
isocitrate + NADP+
Homo sapiens
-
2-oxoglutarate + NADPH + CO2
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.42
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
heart
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
286786
Escherichia coli
2-oxoglutarate + NADPH + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
286786
Homo sapiens
2-oxoglutarate + NADPH + CO2
-
-
-
?