BRENDA - Enzyme Database

Egenschaften der NADP+-abhängigen Isocitratdehydrogenasen aus Acinetobacter calcoaceticus

Kleber, H.P.; Z. Allg. Mikrobiol. 15, 431-435 (1975)

Data extracted from this reference:

General Stability
EC Number
General Stability
Organism
1.1.1.42
low molecular weight form of Acinetobacter calcoaceticus enzyme more heat stable than high molecular weight form
Acinetobacter calcoaceticus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
2-oxoglutarate
substrate inhibition
Acinetobacter calcoaceticus
1.1.1.42
ATP
-
Acinetobacter calcoaceticus
1.1.1.42
glyoxylate
plus oxaloacetate
Acinetobacter calcoaceticus
1.1.1.42
oxaloacetate
-
Acinetobacter calcoaceticus
1.1.1.42
Urea
low molecular weight form
Acinetobacter calcoaceticus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.42
Mg2+
absolute requirement for divalent cations
Acinetobacter calcoaceticus
1.1.1.42
Mn2+
absolute requirement for divalent cations
Acinetobacter calcoaceticus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.1.1.42
90000
-
gel filtration, low molecular weight form
Acinetobacter calcoaceticus
1.1.1.42
360000
-
gel filtration, high molecular weight form
Acinetobacter calcoaceticus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Acinetobacter calcoaceticus
-
2-oxoglutarate + NADPH + CO2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Acinetobacter calcoaceticus
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
286781
Acinetobacter calcoaceticus
2-oxoglutarate + NADPH + CO2
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.42
7.5
-
high molecular weight form
Acinetobacter calcoaceticus
1.1.1.42
8
-
low molecular weight form
Acinetobacter calcoaceticus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Acinetobacter calcoaceticus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Acinetobacter calcoaceticus
General Stability (protein specific)
EC Number
General Stability
Organism
1.1.1.42
low molecular weight form of Acinetobacter calcoaceticus enzyme more heat stable than high molecular weight form
Acinetobacter calcoaceticus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
2-oxoglutarate
substrate inhibition
Acinetobacter calcoaceticus
1.1.1.42
ATP
-
Acinetobacter calcoaceticus
1.1.1.42
glyoxylate
plus oxaloacetate
Acinetobacter calcoaceticus
1.1.1.42
oxaloacetate
-
Acinetobacter calcoaceticus
1.1.1.42
Urea
low molecular weight form
Acinetobacter calcoaceticus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.42
Mg2+
absolute requirement for divalent cations
Acinetobacter calcoaceticus
1.1.1.42
Mn2+
absolute requirement for divalent cations
Acinetobacter calcoaceticus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.1.1.42
90000
-
gel filtration, low molecular weight form
Acinetobacter calcoaceticus
1.1.1.42
360000
-
gel filtration, high molecular weight form
Acinetobacter calcoaceticus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Acinetobacter calcoaceticus
-
2-oxoglutarate + NADPH + CO2
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
286781
Acinetobacter calcoaceticus
2-oxoglutarate + NADPH + CO2
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.42
7.5
-
high molecular weight form
Acinetobacter calcoaceticus
1.1.1.42
8
-
low molecular weight form
Acinetobacter calcoaceticus