Literature summary extracted from

Gabriel, J.L.; Plaut, G.W.E.
Specific site inhibitors of NAD-specific isocitrate dehydrogenase from bovine heart (1981), J. Biol. Chem., 257, 8021-8029.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.41	bilirubin	-	Bos taurus
1.1.1.41	Chicago sky blue	-	Bos taurus
1.1.1.41	Congo red	-	Bos taurus
1.1.1.41	fluorescein	halogenated derivatives	Bos taurus
1.1.1.41	Sulfobromophthalein	-	Bos taurus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1.1.41	0.06	0.09	NAD+	-	Bos taurus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.41	isocitrate + NAD+	Bos taurus	-	2-oxoglutarate + CO2 + NADH + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.41	Bos taurus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.41	heart	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.41	isocitrate + NAD+	-	Bos taurus	2-oxoglutarate + CO2 + NADH + H+	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.41	NAD+	-	Bos taurus

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Release 2023.1 (January 2023)