Literature summary extracted from

Willson, V.J.C.; Tripton, K.F.
The activation of ox-brain NAD+-dependent isocitrate dehydrogenase by magnesium ions (1981), Eur. J. Biochem., 113, 477-483.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.41	ATP	-	Bos taurus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.1.1.41	Ca2+	less effective than Mn2+ or Mg2+	Bos taurus
1.1.1.41	Co2+	less effective than Mg2+ or Mn2+	Bos taurus
1.1.1.41	Mg2+	-	Bos taurus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.41	isocitrate + NAD+	Bos taurus	-	2-oxoglutarate + CO2 + NADH + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.41	Bos taurus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.41	-	Bos taurus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.41	brain	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.41	isocitrate + NAD+	-	Bos taurus	2-oxoglutarate + CO2 + NADH + H+	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.1.1.41	25	-	-	Bos taurus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.41	NAD+	-	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)