BRENDA - Enzyme Database

Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates

Alp, P.R.; Newsholme, E.A.; Zammit, V.A.; Biochem. J. 154, 689-700 (1976)

Data extracted from this reference:

General Stability
EC Number
General Stability
Organism
1.1.1.41
20 h in medium containing ADP
Ovis aries
1.1.1.41
20 h in medium containing ADP
Sarcophaga barbata
1.1.1.41
20 h in medium containing ADP
Periplaneta americana
1.1.1.41
20 h in medium containing ADP
Lepas anatifera
1.1.1.41
20 h in medium containing ADP
Locusta sp.
1.1.1.41
20 h in medium containing ADP
Oryctes rhinoceros
1.1.1.41
20 h in medium containing ADP
waterbug
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.41
Ca2+
-
Lepas anatifera
1.1.1.41
Ca2+
-
Locusta sp.
1.1.1.41
Ca2+
-
Oryctes rhinoceros
1.1.1.41
Ca2+
-
Ovis aries
1.1.1.41
Ca2+
-
Periplaneta americana
1.1.1.41
Ca2+
-
Sarcophaga barbata
1.1.1.41
Ca2+
-
waterbug
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Ovis aries
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Sarcophaga barbata
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Periplaneta americana
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Lepas anatifera
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Locusta sp.
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Oryctes rhinoceros
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
waterbug
-
2-oxoglutarate + CO2 + NADH
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.41
Lepas anatifera
-
-
-
1.1.1.41
Locusta sp.
-
-
-
1.1.1.41
Oryctes rhinoceros
-
-
-
1.1.1.41
Ovis aries
-
-
-
1.1.1.41
Periplaneta americana
-
-
-
1.1.1.41
Sarcophaga barbata
-
-
-
1.1.1.41
waterbug
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
muscle
flight muscle
Lepas anatifera
-
1.1.1.41
muscle
flight muscle
Locusta sp.
-
1.1.1.41
muscle
flight muscle
Oryctes rhinoceros
-
1.1.1.41
muscle
flight muscle
Ovis aries
-
1.1.1.41
muscle
flight muscle
Periplaneta americana
-
1.1.1.41
muscle
flight muscle
Sarcophaga barbata
-
1.1.1.41
muscle
flight muscle
waterbug
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
286753
Ovis aries
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Sarcophaga barbata
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Periplaneta americana
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Lepas anatifera
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Locusta sp.
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Oryctes rhinoceros
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
waterbug
2-oxoglutarate + CO2 + NADH
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.41
25
-
assay condition
Lepas anatifera
1.1.1.41
25
-
assay condition
Locusta sp.
1.1.1.41
25
-
assay condition
Oryctes rhinoceros
1.1.1.41
25
-
assay condition
Ovis aries
1.1.1.41
25
-
assay condition
Periplaneta americana
1.1.1.41
25
-
assay condition
Sarcophaga barbata
1.1.1.41
25
-
assay condition
waterbug
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.41
7
7.2
-
Locusta sp.
1.1.1.41
7.5
-
-
Lepas anatifera
1.1.1.41
7.5
-
-
Locusta sp.
1.1.1.41
7.5
-
-
Oryctes rhinoceros
1.1.1.41
7.5
-
-
Periplaneta americana
1.1.1.41
7.5
-
-
Sarcophaga barbata
1.1.1.41
7.5
-
-
waterbug
1.1.1.41
8.1
-
vertebrate muscle
Ovis aries
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Lepas anatifera
1.1.1.41
NAD+
-
Locusta sp.
1.1.1.41
NAD+
-
Oryctes rhinoceros
1.1.1.41
NAD+
-
Ovis aries
1.1.1.41
NAD+
-
Periplaneta americana
1.1.1.41
NAD+
-
Sarcophaga barbata
1.1.1.41
NAD+
-
waterbug
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Lepas anatifera
1.1.1.41
NAD+
-
Locusta sp.
1.1.1.41
NAD+
-
Oryctes rhinoceros
1.1.1.41
NAD+
-
Ovis aries
1.1.1.41
NAD+
-
Periplaneta americana
1.1.1.41
NAD+
-
Sarcophaga barbata
1.1.1.41
NAD+
-
waterbug
General Stability (protein specific)
EC Number
General Stability
Organism
1.1.1.41
20 h in medium containing ADP
Ovis aries
1.1.1.41
20 h in medium containing ADP
Sarcophaga barbata
1.1.1.41
20 h in medium containing ADP
Periplaneta americana
1.1.1.41
20 h in medium containing ADP
Lepas anatifera
1.1.1.41
20 h in medium containing ADP
Locusta sp.
1.1.1.41
20 h in medium containing ADP
Oryctes rhinoceros
1.1.1.41
20 h in medium containing ADP
waterbug
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.41
Ca2+
-
Lepas anatifera
1.1.1.41
Ca2+
-
Locusta sp.
1.1.1.41
Ca2+
-
Oryctes rhinoceros
1.1.1.41
Ca2+
-
Ovis aries
1.1.1.41
Ca2+
-
Periplaneta americana
1.1.1.41
Ca2+
-
Sarcophaga barbata
1.1.1.41
Ca2+
-
waterbug
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Ovis aries
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Sarcophaga barbata
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Periplaneta americana
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Lepas anatifera
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Locusta sp.
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Oryctes rhinoceros
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
waterbug
-
2-oxoglutarate + CO2 + NADH
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
muscle
flight muscle
Lepas anatifera
-
1.1.1.41
muscle
flight muscle
Locusta sp.
-
1.1.1.41
muscle
flight muscle
Oryctes rhinoceros
-
1.1.1.41
muscle
flight muscle
Ovis aries
-
1.1.1.41
muscle
flight muscle
Periplaneta americana
-
1.1.1.41
muscle
flight muscle
Sarcophaga barbata
-
1.1.1.41
muscle
flight muscle
waterbug
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
286753
Ovis aries
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Sarcophaga barbata
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Periplaneta americana
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Lepas anatifera
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Locusta sp.
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
Oryctes rhinoceros
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
286753
waterbug
2-oxoglutarate + CO2 + NADH
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.41
25
-
assay condition
Lepas anatifera
1.1.1.41
25
-
assay condition
Locusta sp.
1.1.1.41
25
-
assay condition
Oryctes rhinoceros
1.1.1.41
25
-
assay condition
Ovis aries
1.1.1.41
25
-
assay condition
Periplaneta americana
1.1.1.41
25
-
assay condition
Sarcophaga barbata
1.1.1.41
25
-
assay condition
waterbug
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.41
7
7.2
-
Locusta sp.
1.1.1.41
7.5
-
-
Lepas anatifera
1.1.1.41
7.5
-
-
Locusta sp.
1.1.1.41
7.5
-
-
Oryctes rhinoceros
1.1.1.41
7.5
-
-
Periplaneta americana
1.1.1.41
7.5
-
-
Sarcophaga barbata
1.1.1.41
7.5
-
-
waterbug
1.1.1.41
8.1
-
vertebrate muscle
Ovis aries