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Literature summary extracted from

  • Hoek, H.B.; Pearson, D.J.; Olembo, N.K.
    Nicotinamide-adenine dinucleotide-linked malic enzyme in flight muscle of the tse-tse fly (Glossina) and other insects (1976), Biochem. J., 160, 253-262.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.39 0.21
-
 NAD+
-
 Glossina morsitans
1.1.1.39 2.5
-
 (S)-malate
-
 Glossina morsitans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.39 cytosol 30% of the activity Glossina morsitans 5829
-
1.1.1.39 mitochondrion 65% of the activity Glossina morsitans 5739
-
1.1.1.39 mitochondrion predominantly in the matrix space Glossina morsitans 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.39 Mg2+ completely dependent on the presence of Mg2+ or Mn2+ Glossina morsitans
1.1.1.39 Mn2+ completely dependent on the presence of Mg2+ or Mn2+ Glossina morsitans

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.39 Apis mellifera
-
-
-
1.1.1.39 Glossina austeni
-
-
-
1.1.1.39 Glossina longipennis
-
-
-
1.1.1.39 Glossina morsitans
-
-
-
1.1.1.39 Glossina pallidipes
-
-
-
1.1.1.39 Heliocarpus sp.
-
-
-
1.1.1.39 Odontotermes sp.
-
-
-
1.1.1.39 Periplaneta americana
-
-
-
1.1.1.39 Sarcophaga sp.
-
-
-
1.1.1.39 Schistocerca gregaria
-
-
-
1.1.1.39 Spodoptera exempta
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.39 flight muscle
-
 Glossina morsitans
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.39 24
-
-
 Glossina morsitans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.39 (S)-malate + NADP+ at 1.5% of the activity with NAD+ Glossina morsitans pyruvate + CO2 + NADPH
-
 ?
1.1.1.39 malate + NAD+
-
 Schistocerca gregaria pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Apis mellifera pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Glossina longipennis pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Glossina morsitans pyruvate + CO2 + NADH + H+
-
 ir
1.1.1.39 malate + NAD+
-
 Glossina austeni pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Glossina pallidipes pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Sarcophaga sp. pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Periplaneta americana pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Odontotermes sp. pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Spodoptera exempta pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Heliocarpus sp. pyruvate + CO2 + NADH + H+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.39 7.6 7.9
-
 Glossina morsitans

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.39 7 8.7 pH 7.0: about 30% of maximal activity, pH 8.7: about 45% of maximal activity Glossina morsitans

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.39 NAD+ cofactor Schistocerca gregaria
1.1.1.39 NAD+ cofactor Apis mellifera
1.1.1.39 NAD+ cofactor Glossina longipennis
1.1.1.39 NAD+ cofactor Glossina morsitans
1.1.1.39 NAD+ cofactor Glossina austeni
1.1.1.39 NAD+ cofactor Glossina pallidipes
1.1.1.39 NAD+ cofactor Sarcophaga sp.
1.1.1.39 NAD+ cofactor Periplaneta americana
1.1.1.39 NAD+ cofactor Odontotermes sp.
1.1.1.39 NAD+ cofactor Spodoptera exempta
1.1.1.39 NAD+ cofactor Heliocarpus sp.
1.1.1.39 NADP+ at 1.5% of the activity with NAD+ Glossina morsitans