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Literature summary extracted from

  • Day, D.A.; Neuburger, M.; Douce, R.
    Activation of NAD-linked malic enzyme in intact plant mitochondria by exogenous coenzyme A (1984), Arch. Biochem. Biophys., 231, 233-242.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.39 coenzyme A serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity Solanum tuberosum
1.1.1.39 coenzyme A serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity Brassica oleracea

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.39 oxaloacetate
-
 Brassica oleracea
1.1.1.39 oxaloacetate
-
 Solanum tuberosum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.39 mitochondrion
-
 Solanum tuberosum 5739
-
1.1.1.39 mitochondrion
-
 Brassica oleracea 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.39 (S)-malate + NAD+ Solanum tuberosum the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation ?
-
 ?
1.1.1.39 (S)-malate + NAD+ Brassica oleracea the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.39 Brassica oleracea
-
-
-
1.1.1.39 Solanum tuberosum
-
 var. urgenta
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.39 bud
-
 Solanum tuberosum
-
1.1.1.39 bud
-
 Brassica oleracea
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.39 (S)-malate + NAD+ the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation Solanum tuberosum ?
-
 ?
1.1.1.39 (S)-malate + NAD+ the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation Brassica oleracea ?
-
 ?
1.1.1.39 malate + NAD+
-
 Solanum tuberosum pyruvate + CO2 + NADH + H+
-
 ?
1.1.1.39 malate + NAD+
-
 Brassica oleracea pyruvate + CO2 + NADH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.39 NAD+ cofactor Solanum tuberosum
1.1.1.39 NAD+ cofactor Brassica oleracea