EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.1.1.37 | - |
Sulfolobus acidocaldarius |
1.1.1.37 | in presence of ethylene glycol 4000 | Sulfolobus acidocaldarius |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.37 | (S)-malate | product inhibition, 66% inhibition at 5 mM | Sulfolobus acidocaldarius | |
1.1.1.37 | 2-oxoglutarate | 44% inhibition at 5 mM | Sulfolobus acidocaldarius | |
1.1.1.37 | alpha-ketoglutarate | - |
Methanospirillum hungatei | |
1.1.1.37 | alpha-ketoglutarate | - |
Sulfolobus acidocaldarius | |
1.1.1.37 | L-malate | - |
Methanospirillum hungatei | |
1.1.1.37 | L-malate | product inhibition | Sulfolobus acidocaldarius | |
1.1.1.37 | L-malate | - |
Sus scrofa | |
1.1.1.37 | additional information | not inhibitory: AMP, ADP, ATP | Sulfolobus acidocaldarius | |
1.1.1.37 | NAD+ | product inhibition; product inhibition, 29% inhibition at 5 mM, 42% inhibition at 10 mM | Sulfolobus acidocaldarius | |
1.1.1.37 | NADP+ | product inhibition; product inhibition, 26% inhibition at 10 mM | Sulfolobus acidocaldarius | |
1.1.1.37 | oxaloacetate | substrate inhibition; substrate inhibition, 29% inhibition at 5 mM | Sulfolobus acidocaldarius | |
1.1.1.37 | oxaloacetate | - |
Sus scrofa | |
1.1.1.37 | oxaloacetate | substrate inhibition | Thermus thermophilus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.37 | 0.0041 | - |
NADH | - |
Sulfolobus acidocaldarius | |
1.1.1.37 | 0.0041 | - |
NADH | 40°C, pH 5.8 | Sulfolobus acidocaldarius | |
1.1.1.37 | 0.052 | - |
oxaloacetate | - |
Sulfolobus acidocaldarius | |
1.1.1.37 | 0.052 | - |
oxaloacetate | 40°C, pH 5.8 | Sulfolobus acidocaldarius | |
1.1.1.37 | 0.2 | - |
NADPH | - |
Sulfolobus acidocaldarius |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.37 | 34000 | - |
4 * 34000, SDS-PAGE | Sulfolobus acidocaldarius |
1.1.1.37 | 97000 | - |
gel filtration | Sulfolobus acidocaldarius |
1.1.1.37 | 128500 | - |
ultracentrifugation | Sulfolobus acidocaldarius |
1.1.1.37 | 128500 | - |
ultracentrifugation, sedimentation equilibrium studies | Sulfolobus acidocaldarius |
1.1.1.37 | 134000 | - |
cross-linking data | Sulfolobus acidocaldarius |
1.1.1.37 | 134000 | - |
SDS-PAGE of enzyme after cross-linking | Sulfolobus acidocaldarius |
1.1.1.37 | 140000 | - |
- |
Laceyella sacchari |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.37 | malate + NAD+ | Thermus aquaticus | - |
oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | Thermus thermophilus | - |
oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | Escherichia coli | - |
oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | Sus scrofa | - |
oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | Methanothermobacter thermautotrophicus | - |
oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | Sulfolobus acidocaldarius | - |
oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | Thermoplasma acidophilum | - |
oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | Laceyella sacchari | - |
oxaloacetate + NADH + H+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.37 | Escherichia coli | - |
- |
- |
1.1.1.37 | Laceyella sacchari | - |
- |
- |
1.1.1.37 | Methanospirillum hungatei | - |
- |
- |
1.1.1.37 | Methanothermobacter thermautotrophicus | - |
- |
- |
1.1.1.37 | Sulfolobus acidocaldarius | - |
- |
- |
1.1.1.37 | Sus scrofa | - |
pig | - |
1.1.1.37 | Thermoplasma acidophilum | - |
- |
- |
1.1.1.37 | Thermus aquaticus | - |
- |
- |
1.1.1.37 | Thermus thermophilus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.37 | - |
Sulfolobus acidocaldarius |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.37 | heart | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.37 | 1.5 | - |
L-malate oxidation in presence of NAD+ | Sulfolobus acidocaldarius |
1.1.1.37 | 277 | - |
- |
Sulfolobus acidocaldarius |
1.1.1.37 | 277 | - |
40°C, pH 5.8 | Sulfolobus acidocaldarius |
EC Number | Storage Stability | Organism |
---|---|---|
1.1.1.37 | -20°C, can be stored over months | Sulfolobus acidocaldarius |
1.1.1.37 | 4°C, pH 7.0-9.0, concentration of 0.0018 mg/ml, quite stable. Below pH 7.0, inactivation occurs | Sulfolobus acidocaldarius |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.37 | (S)-malate + NAD+ | - |
Thermus aquaticus | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | - |
Thermus thermophilus | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | - |
Escherichia coli | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | - |
Methanothermobacter thermautotrophicus | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | - |
Sulfolobus acidocaldarius | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | - |
Thermoplasma acidophilum | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | - |
Laceyella sacchari | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | (S)-malate + NAD+ | low activity in this direction | Sulfolobus acidocaldarius | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Thermus aquaticus | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Thermus thermophilus | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Escherichia coli | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Methanothermobacter thermautotrophicus | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Sulfolobus acidocaldarius | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Thermoplasma acidophilum | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | malate + NAD+ | - |
Laceyella sacchari | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Thermus aquaticus | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Thermus thermophilus | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Escherichia coli | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Sus scrofa | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Methanothermobacter thermautotrophicus | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Sulfolobus acidocaldarius | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Thermoplasma acidophilum | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH | - |
Methanospirillum hungatei | L-malate + NAD+ | - |
? | |
1.1.1.37 | oxaloacetate + NADH | - |
Laceyella sacchari | L-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADH + H+ | - |
Sulfolobus acidocaldarius | (S)-malate + NAD+ | - |
r | |
1.1.1.37 | oxaloacetate + NADPH + H+ | - |
Sulfolobus acidocaldarius | (S)-malate + NADP+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.37 | tetramer | - |
Escherichia coli |
1.1.1.37 | tetramer | - |
Thermoplasma acidophilum |
1.1.1.37 | tetramer | - |
Laceyella sacchari |
1.1.1.37 | tetramer | 4 * 34000, SDS-PAGE | Sulfolobus acidocaldarius |
EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.37 | 8 | 80 | - |
Sulfolobus acidocaldarius |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.37 | additional information | - |
activity of purified enzyme decreases continually from 4°C to 80°C | Sulfolobus acidocaldarius |
1.1.1.37 | 75 | - |
15 min, 75% residual activity, purified enzyme | Sulfolobus acidocaldarius |
1.1.1.37 | 80 | - |
15 min, no loss of activity, enzyme in crude extract | Sulfolobus acidocaldarius |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.37 | 2.62 | - |
oxaloacetate | - |
Sulfolobus acidocaldarius |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.37 | 3 | - |
complete inactivation | Sulfolobus acidocaldarius |
1.1.1.37 | 5.5 | - |
24 h, 50% loss of activity | Sulfolobus acidocaldarius |
1.1.1.37 | 7 | - |
inactivation below | Sulfolobus acidocaldarius |
1.1.1.37 | 7 | 9 | quite stable | Sulfolobus acidocaldarius |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.37 | NAD+ | - |
Sulfolobus acidocaldarius | |
1.1.1.37 | NAD+ | - |
Thermoplasma acidophilum | |
1.1.1.37 | NADH | A-side stereospecificity | Sulfolobus acidocaldarius | |
1.1.1.37 | NADP+ | - |
Sulfolobus acidocaldarius | |
1.1.1.37 | NADP+ | - |
Thermoplasma acidophilum | |
1.1.1.37 | NADPH | A-side stereospecificity | Sulfolobus acidocaldarius |