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Literature summary extracted from
- Characterization of acetoacetyl-CoA reductase (3-oxoreductase) from Streptomyces coelicolor: Its possible role in polyhydroxybutyrate biosynthesis (1973), Biochem. Soc. Trans., 11, 598-599.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.36 | additional information | not inhibited by acetoacetyl-CoA at high concentrations | Streptomyces coelicolor |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.36 | 0.008 | - |
S-acetoacetyl-N-acetylcysteamine | cofactor NADH | Streptomyces coelicolor |  |
| 1.1.1.36 | 0.01 | - |
acetoacetyl-CoA | cofactor NADPH | Streptomyces coelicolor | |
| 1.1.1.36 | 0.018 | - |
acetoacetyl-CoA | cofactor NADH | Streptomyces coelicolor | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.36 | 55000 | - |
2 * 55000 + 2 * 65000, SDS-PAGE | Streptomyces coelicolor |
| 1.1.1.36 | 65000 | - |
2 * 55000 + 2 * 65000, SDS-PAGE | Streptomyces coelicolor |
| 1.1.1.36 | 250000 | - |
gel filtration | Streptomyces coelicolor |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.36 | Streptomyces coelicolor | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.36 | gel-filtration Sephadex G-200, DEAE-cellulose chromatography, sucrose-gradient centrifugation | Streptomyces coelicolor |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.36 | acetoacetyl-CoA + NADPH + H+ | - |
Streptomyces coelicolor | (3R)-3-hydroxybutyryl-CoA + NADP+ | - |
r | |
| 1.1.1.36 | additional information | not: crotonyl-CoA | Streptomyces coelicolor | ? | - |
? | |
| 1.1.1.36 | S-acetoacetyl-N-acetylcysteamine + NADPH | - |
Streptomyces coelicolor | 3-hydroxybutyryl-N-acetylcysteamine + NADP+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.36 | tetramer | 2 * 55000 + 2 * 65000, SDS-PAGE | Streptomyces coelicolor |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.36 | NADH | - |
Streptomyces coelicolor | |
| 1.1.1.36 | NADPH | - |
Streptomyces coelicolor | |
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Release 2023.1 (January 2023)
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