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Literature summary extracted from
- Studies on the mechanism of fatty acid synthesis (1962), J. Biol. Chem., 237, 687-693.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.36 | additional information | not inhibited by p-hydroxymercuribenzoate or N-ethylmaleimide from 0.1-10 mM | Pigeon |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.36 | 0.74 | - |
acetoacetyl-CoA | - |
Pigeon |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.36 | Pigeon | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.36 | fractionated with ammonium sulfate | Pigeon |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.36 | liver | - |
Pigeon | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.36 | 87.9 | - |
fed pigeons livers | Pigeon |
| 1.1.1.36 | 170.1 | - |
fasted pigeons livers | Pigeon |
| 1.1.1.36 | 250 | - |
- |
Pigeon |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.36 | acetoacetyl-CoA + NADPH + H+ | - |
Pigeon | D-beta-hydroxybutyryl-CoA + NADP+ | - |
ir | |
| 1.1.1.36 | acetoacetyl-CoA + NADPH + H+ | - |
Pigeon | (3R)-3-hydroxybutyryl-CoA + NADP+ | - |
r | |
| 1.1.1.36 | additional information | not: crotonyl-CoA | Pigeon | ? | - |
? | |
| 1.1.1.36 | additional information | not: octanoyl-CoA | Pigeon | ? | - |
? | |
| 1.1.1.36 | additional information | not: beta-hydroxybutyryl-CoA | Pigeon | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.36 | 37 | - |
- |
Pigeon |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.36 | 6.5 | 8.5 | 70-35% of initial acetoacetyl-CoA reduced | Pigeon |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.36 | additional information | - |
above pH 8.5 acetoacetyl-CoA not stable | Pigeon |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.36 | NADP+ | - |
Pigeon | |
| 1.1.1.36 | NADPH | - |
Pigeon | |
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Release 2023.1 (January 2023)
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