Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • He, X.Y.; Schulz, H.; Yang, S.Y.
    a human brain L-3-hydroxyacyl-coenzyme a dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease (1998), J. Biol. Chem., 273, 10741-10746.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.35
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.35 0.02
-
 NADH enzyme from brain Homo sapiens
1.1.1.35 0.089
-
 acetoacetyl-CoA enzyme from brain Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.35 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.1.1.35 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.35 27000
-
 4 * 27000, enzyme from brain, SDS-PAGE Homo sapiens
1.1.1.35 108000
-
 enzyme from brain, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+ Homo sapiens
-
 acetoacetyl-CoA + NADH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Homo sapiens Q99714
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.35 overexpressed in Escherichia coli, hydroxylapatite Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.35 brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.35 17.35
-
 enzyme from brain Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+
-
 Homo sapiens acetoacetyl-CoA + NADH
-
 r
1.1.1.35 3-ketohexadecanoyl-CoA + NADH
-
 Homo sapiens (S)-3-hydroxhexadecanoyl-CoA + NAD+
-
 r
1.1.1.35 3-ketooctanoyl-CoA + NADH
-
 Homo sapiens (S)-3-hydroxyoctanoyl-CoA + NAD+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.35 tetramer 4 * 27000, enzyme from brain, SDS-PAGE Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.35 24
-
 3-ketohexdecanoyl-CoA enzyme from brain, pH 7.0 Homo sapiens
1.1.1.35 28
-
 3-ketooctanoyl-CoA enzyme from brain, pH 7.0 Homo sapiens
1.1.1.35 37
-
 acetoacetyl-CoA enzyme from brain, pH 7.0 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.35 NAD+
-
 Homo sapiens