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Literature summary extracted from

  • Friesen, J.A.; Rodwell, V.W.
    Identification of elements critical for phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by adenosine monophosphate-activated protein kinase: Protein engineering of the naturally nonephosphorylatable 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pseudomonas mevalonii (1997), Biochemistry, 36, 1157-1162.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.34 expression in Escherichia coli Pseudomonas mevalonii

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.34 R387S regulation of activity by phosphorylation Pseudomonas mevalonii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Pseudomonas mevalonii
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Pseudomonas mevalonii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Pseudomonas mevalonii (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Pseudomonas mevalonii