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Literature summary extracted from
- Purification and characterization of 3-hydroxymethylglutaryl-coenzyme A reductase of Schistosoma mansoni: Regulation of parasite enzyme activity differs from mammalien host (1991), Exp. Parasitol., 73, 82-92.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.34 | lovastatin | - |
Schistosoma mansoni |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.34 | 0.003 | - |
3-hydroxy-3-methylglutaryl-CoA | - |
Schistosoma mansoni | |
| 1.1.1.34 | 0.052 | - |
NADPH | - |
Schistosoma mansoni | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 66000 | - |
gel filtration | Schistosoma mansoni |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Schistosoma mansoni | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.34 | Schistosoma mansoni | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.34 | - |
Schistosoma mansoni |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 0.0036 | - |
- |
Schistosoma mansoni |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.1.1.34 | -20°C, crude enzyme, 30 days, no loss in activity | Schistosoma mansoni |
| 1.1.1.34 | -20°C, partially purified enzyme, 24-48 h, loss of most of activity | Schistosoma mansoni |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Schistosoma mansoni | (R)-mevalonate + CoA + NADP+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.34 | monomer | 1 * 66000, SDS-PAGE | Schistosoma mansoni |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.34 | NADPH | - |
Schistosoma mansoni | |
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Release 2023.1 (January 2023)
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