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Literature summary extracted from

  • Madhosingh, C.; Migicovski, B.B.; Wood, I.M.
    Inhibition of yeast hydroxymethylglutaryl-CoA reductase by a rat liver mitochondrial preperation (1974), FEBS Lett., 46, 20-22.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 cytosol
-
 Saccharomyces cerevisiae 5829
-
1.1.1.34 microsome
-
 Rattus norvegicus
-
-
1.1.1.34 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Rattus norvegicus
-
 (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Saccharomyces cerevisiae
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Rattus norvegicus
-
-
-
1.1.1.34 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.34
-
 Rattus norvegicus
1.1.1.34
-
 Saccharomyces cerevisiae

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Storage Stability

EC Number Storage Stability Organism
1.1.1.34 -20°C, after quick freezing in acetone/solid CO2 at -80°C, one week, 10% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Rattus norvegicus (R)-mevalonate + CoA + NADP+
-
 ?
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Saccharomyces cerevisiae (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Rattus norvegicus
1.1.1.34 NADPH
-
 Saccharomyces cerevisiae