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Literature summary extracted from
- The reduction of beta-hydroxy-beta-methylglutaryl coenzyme A to mevalonic acid (1960), J. Biol. Chem., 235, 2572-2578.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.34 | CoASH | - |
Saccharomyces cerevisiae |  |
| 1.1.1.34 | p-hydroxymercuribenzoate | 3.7 mM, complete inhibition | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Saccharomyces cerevisiae | - |
(R)-mevalonate + CoA + NADP+ | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.34 | Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.34 | - |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.34 | 0.0035 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Saccharomyces cerevisiae | (R)-mevalonate + CoA + NADP+ | - |
ir | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.34 | NADPH | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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