Literature summary extracted from

Kluger, R.; Nakaoka, K.; Tsui, W.C.
Substrate analogue studies of the specificity and catalytic mechanism of D-3-hydroxybutyrate dehydrogenase (1978), J. Am. Chem. Soc., 100, 7388-7392.

No PubMed abstract available

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.30	phosphatidylcholine	-	Paucimonas lemoignei

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.30	acetylphosphonate	16.7 mM, pH 7, 28% inhibition	Paucimonas lemoignei
1.1.1.30	dimethyl phosphate	16.7 mM, pH 7, 12% inhibition	Paucimonas lemoignei
1.1.1.30	methanephosphonic acid	3.3 mM, pH 7, 11% inhibition	Paucimonas lemoignei
1.1.1.30	methyl methylphosphonate	3.3 mM, pH 7, 13% inhibition	Paucimonas lemoignei
1.1.1.30	methyl phosphate	16.7 mM, pH 7, 21% inhibition	Paucimonas lemoignei
1.1.1.30	oxalate	16.7 mM, pH 7, 9% inhibition	Paucimonas lemoignei
1.1.1.30	pyruvate	16.7 mM, pH 7.0, 22% inhibition	Paucimonas lemoignei
1.1.1.30	sodium acetonylphosphonate	3.3 mM, pH 7, 21% inhibition	Paucimonas lemoignei
1.1.1.30	sodium monomethyl acetylphosphonate	16.7 mM, pH 7, 60% inhibition	Paucimonas lemoignei
1.1.1.30	sodium monomethylacetonylphosphate	16.7 mM, pH 7, 30% inhibition	Paucimonas lemoignei

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.30	(R)-3-hydroxybutanoate + NAD+	Paucimonas lemoignei	-	acetoacetate + NADH	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.30	Paucimonas lemoignei	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.30	(R)-3-hydroxybutanoate + NAD+	-	Paucimonas lemoignei	acetoacetate + NADH	-	r
1.1.1.30	2-hydroxypropansulfonate + NAD+	-	Paucimonas lemoignei	acetonylsulfonate + NADH	-	r
1.1.1.30	2-methyl-3-hydroxybutyrate + NAD+	-	Paucimonas lemoignei	2-methylacetoacetate + NADH	-	r

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.1.1.30	6	6.5	reduction of acetoacetate	Paucimonas lemoignei

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.30	NAD+	-	Paucimonas lemoignei

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Release 2023.1 (January 2023)