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Literature summary extracted from

  • Vanden Bossche, H.; Marichal, P.; Le Jeune, L.; Coene, M.C.; Gorrens, J.; Cools, W.
    Effects of itraconazole on cytochrome P-450-dependent sterol 14alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans (1993), Antimicrob. Agents Chemother., 37, 2101-2105.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.270 itraconazole triazole antifungal agent, inhibits NADPH-dependent 3-ketosteroid reductase directly or indirectly Cryptococcus neoformans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.270 additional information Cryptococcus neoformans enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.270 Cryptococcus neoformans
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var. neoformans, B42419, ATCC 32265, pathogenic fungus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.270 additional information NADPH-dependent 3-ketosteroid reductase catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group Cryptococcus neoformans ?
-
?
1.1.1.270 additional information enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 Cryptococcus neoformans ?
-
?
1.1.1.270 obtusifolione + NADPH 4,14-dimethyl-ergosta-8,24(28)-dien-3-one Cryptococcus neoformans obtusifoliol + NADP+ 4,14-dimethyl-ergosta-8,24(28)-dien-3-ol ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.270 NADPH NADPH-dependent Cryptococcus neoformans