EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.270 | itraconazole | triazole antifungal agent, inhibits NADPH-dependent 3-ketosteroid reductase directly or indirectly | Cryptococcus neoformans |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.270 | additional information | Cryptococcus neoformans | enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.270 | Cryptococcus neoformans | - |
var. neoformans, B42419, ATCC 32265, pathogenic fungus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.270 | additional information | NADPH-dependent 3-ketosteroid reductase catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group | Cryptococcus neoformans | ? | - |
? | |
1.1.1.270 | additional information | enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 | Cryptococcus neoformans | ? | - |
? | |
1.1.1.270 | obtusifolione + NADPH | 4,14-dimethyl-ergosta-8,24(28)-dien-3-one | Cryptococcus neoformans | obtusifoliol + NADP+ | 4,14-dimethyl-ergosta-8,24(28)-dien-3-ol | ? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.270 | NADPH | NADPH-dependent | Cryptococcus neoformans |