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Literature summary extracted from

  • Davies, D.D.; Davies, S.
    Purification and properties of L(+)-lactate dehydrogenase from potato tubers (1972), Biochem. J., 129, 831-839.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.27 2-glycerophosphate activation Solanum tuberosum
1.1.1.27 3-phosphoglycerate activation Solanum tuberosum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 ADP
-
 Solanum tuberosum
1.1.1.27 ATP at neutral or alkaline pH ATP behaves as a weak competitive inhibitor, potent inhibitor at acid pH values Solanum tuberosum
1.1.1.27 GTP
-
 Solanum tuberosum
1.1.1.27 NAD+ product inhibition Solanum tuberosum
1.1.1.27 NADH competitive with respect to NAD+ Solanum tuberosum
1.1.1.27 oxalate
-
 Solanum tuberosum
1.1.1.27 phosphoenolpyruvate
-
 Solanum tuberosum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.27 0.2
-
 pyruvate
-
 Solanum tuberosum
1.1.1.27 8
-
 Hydroxypyruvate
-
 Solanum tuberosum
1.1.1.27 25
-
 glyoxylate
-
 Solanum tuberosum
1.1.1.27 77
-
 2-oxobutanoate
-
 Solanum tuberosum

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Solanum tuberosum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.27
-
 Solanum tuberosum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 tuber
-
 Solanum tuberosum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.27 18.5
-
-
 Solanum tuberosum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 2-oxobutyrate + NADH
-
 Solanum tuberosum 2-hydroxybutyrate + NAD+
-
 ?
1.1.1.27 glyoxylate + NADH
-
 Solanum tuberosum glycolate + NAD+
-
 ?
1.1.1.27 hydroxypyruvate + NADPH + H+
-
 Solanum tuberosum 2,3-dihydroxypropanoate + NADP+
-
 ?
1.1.1.27 pyruvate + NADH + H+
-
 Solanum tuberosum (S)-lactate + NAD+
-
 ?
1.1.1.27 pyruvate + NADPH + H+
-
 Solanum tuberosum (S)-lactate + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.27 6.5
-
 reduction of oxo acids with NADH or NADPH Solanum tuberosum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 NADH coenzyme Solanum tuberosum
1.1.1.27 NADPH coenzyme Solanum tuberosum