Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mahmoud, S.S.; Croteau, R.B.
    Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase (2001), Proc. Natl. Acad. Sci. USA, 98, 8915-8920.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.267 overexpression and antisense downregulation in transformed peppermint plants Mentha x piperita
1.14.14.143 expression of a homologous antisense version of the menthofuran synthase cDNA, both driven by the CaMV 35S promoter, in Mentha x piperita plants using Agrobacterium tumefaciens strain EHA105 transfection method Mentha x piperita

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.143 additional information expression of a homologous antisense version of the menthofuran synthase cDNA, both driven by the CaMV 35S promoter, in Mentha x piperita plants leads to altered essential oil composition very similar in composition to the DXR46 plant transformed with the sense version of the reductoisomerase, overview Mentha x piperita

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.14.143 Mg2+
-
 Mentha x piperita

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Mentha x piperita
-
 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ir
1.14.14.143 (+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 Mentha x piperita the principal pathway for monoterpene biosynthesis in peppermint, overview (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 Mentha x piperita
-
 peppermint
-
1.14.14.143 Mentha x piperita
-
 cv. Black Mitcham
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.143 leaf
-
 Mentha x piperita
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
 Mentha x piperita 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ir
1.14.14.143 (+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
-
 Mentha x piperita (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.143 (+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 the principal pathway for monoterpene biosynthesis in peppermint, overview Mentha x piperita (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.267 1-deoxyxylulose-5-phosphate reductoisomerase
-
 Mentha x piperita
1.1.1.267 DXR
-
 Mentha x piperita
1.14.14.143 (+)-MFS
-
 Mentha x piperita
1.14.14.143 menthofuran synthase
-
 Mentha x piperita
1.14.14.143 MFS
-
 Mentha x piperita

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.267 NADP+
-
 Mentha x piperita