BRENDA - Enzyme Database

Distribution of enzymes involved in the metabolism of glycyrrhizin in various organs of rat

Akao, T.; Biol. Pharm. Bull. 21, 1036-1044 (1998) View publication on PubMed

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.230
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
3.2.1.128
glycyrrhizinic acid + H2O
Rattus norvegicus
enzyme is involved in glycyrrhizin pathway
glycyrrhetinic acid + D-glucuronyl beta-1,2-D-glucuronic acid
-
Rattus norvegicus
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.1.1.230
Rattus norvegicus
-
-
-
3.2.1.128
Rattus norvegicus
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
Reaction ID
3.2.1.128
glycyrrhizin + H2O = beta-D-glucuronosyl-(1->2)-D-glucuronate + glycyrrhetinate
pathway
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.230
liver
-
Rattus norvegicus
-
3.2.1.128
brain
the highest activity
Rattus norvegicus
-
3.2.1.128
cecum
-
Rattus norvegicus
-
3.2.1.128
colon
-
Rattus norvegicus
-
3.2.1.128
heart
-
Rattus norvegicus
-
3.2.1.128
kidney
-
Rattus norvegicus
-
3.2.1.128
liver
-
Rattus norvegicus
-
3.2.1.128
lung
-
Rattus norvegicus
-
3.2.1.128
spleen
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.1.1.230
0.00002
-
enzyme activity in microsomal fraction of liver homogenate
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3.2.1.128
glycyrrhizinic acid + H2O
-
286343
Rattus norvegicus
glycyrrhetinic acid + D-glucuronyl beta-1,2-D-glucuronic acid
-
286343
Rattus norvegicus
?
3.2.1.128
glycyrrhizinic acid + H2O
enzyme is involved in glycyrrhizin pathway
286343
Rattus norvegicus
glycyrrhetinic acid + D-glucuronyl beta-1,2-D-glucuronic acid
-
286343
Rattus norvegicus
?
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.230
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
3.2.1.128
glycyrrhizinic acid + H2O
Rattus norvegicus
enzyme is involved in glycyrrhizin pathway
glycyrrhetinic acid + D-glucuronyl beta-1,2-D-glucuronic acid
-
Rattus norvegicus
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.230
liver
-
Rattus norvegicus
-
3.2.1.128
brain
the highest activity
Rattus norvegicus
-
3.2.1.128
cecum
-
Rattus norvegicus
-
3.2.1.128
colon
-
Rattus norvegicus
-
3.2.1.128
heart
-
Rattus norvegicus
-
3.2.1.128
kidney
-
Rattus norvegicus
-
3.2.1.128
liver
-
Rattus norvegicus
-
3.2.1.128
lung
-
Rattus norvegicus
-
3.2.1.128
spleen
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.1.1.230
0.00002
-
enzyme activity in microsomal fraction of liver homogenate
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3.2.1.128
glycyrrhizinic acid + H2O
-
286343
Rattus norvegicus
glycyrrhetinic acid + D-glucuronyl beta-1,2-D-glucuronic acid
-
286343
Rattus norvegicus
?
3.2.1.128
glycyrrhizinic acid + H2O
enzyme is involved in glycyrrhizin pathway
286343
Rattus norvegicus
glycyrrhetinic acid + D-glucuronyl beta-1,2-D-glucuronic acid
-
286343
Rattus norvegicus
?