Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Adams, E.
    The enzymatic synthesis of histidine from histidinol (1954), J. Biol. Chem., 209, 829-846.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.23 Borate 10 mM, 90% inhibition Paenarthrobacter histidinolovorans
1.1.1.23 EDTA 30 mM, 50% inhibition at pH 7.5 Paenarthrobacter histidinolovorans
1.1.1.23 p-chloromercuribenzoate 0.02 mM, 50% inhibition Paenarthrobacter histidinolovorans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.23 0.08
-
 NAD+
-
 Paenarthrobacter histidinolovorans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O Escherichia coli reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O Paenarthrobacter histidinolovorans reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Escherichia coli
-
 L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Paenarthrobacter histidinolovorans
-
 L-histidine + 2 NADH + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.23 Escherichia coli
-
-
-
1.1.1.23 Paenarthrobacter histidinolovorans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Escherichia coli L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Paenarthrobacter histidinolovorans L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Escherichia coli L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Paenarthrobacter histidinolovorans L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Escherichia coli L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Paenarthrobacter histidinolovorans L-histidine + 2 NADH + 2 H+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.23 8.6
-
 crude extracts Escherichia coli
1.1.1.23 8.7
-
 partly purified enzyme Paenarthrobacter histidinolovorans

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.23 NAD+
-
 Escherichia coli
1.1.1.23 NAD+
-
 Paenarthrobacter histidinolovorans