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Literature summary extracted from

  • Lindsay, J.A.; Creaser, E.H.
    Purification and properties of histidinol dehydrogenases from psychrophilic, mesophilic and thermophilic bacilli (1977), Biochem. J., 165, 247-253.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.23 0.048
-
 L-histidinol
-
 Bacillus subtilis
1.1.1.23 0.048
-
 L-histidinol
-
 Geobacillus stearothermophilus
1.1.1.23 0.048
-
 L-histidinol
-
 [Bacillus] caldolyticus
1.1.1.23 0.048
-
 L-histidinol
-
 Sporosarcina psychrophila
1.1.1.23 0.2
-
 NAD+
-
 Bacillus subtilis
1.1.1.23 0.2
-
 NAD+
-
 Geobacillus stearothermophilus
1.1.1.23 0.2
-
 NAD+
-
 [Bacillus] caldolyticus
1.1.1.23 0.2
-
 NAD+
-
 Sporosarcina psychrophila

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.23 29000
-
 sedimentation equilibrium Bacillus subtilis
1.1.1.23 29000
-
 sedimentation equilibrium Geobacillus stearothermophilus
1.1.1.23 29000
-
 sedimentation equilibrium [Bacillus] caldolyticus
1.1.1.23 29000
-
 sedimentation equilibrium Sporosarcina psychrophila

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O Bacillus subtilis reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O Geobacillus stearothermophilus reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O [Bacillus] caldolyticus reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O Sporosarcina psychrophila reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O Bacillus subtilis HT1 reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Bacillus subtilis
-
 L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Geobacillus stearothermophilus
-
 L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O [Bacillus] caldolyticus
-
 L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Sporosarcina psychrophila
-
 L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Bacillus subtilis HT1
-
 L-histidine + 2 NADH + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.23 Bacillus subtilis
-
-
-
1.1.1.23 Bacillus subtilis
-
 obtained by transformation
-
1.1.1.23 Bacillus subtilis HT1
-
 obtained by transformation
-
1.1.1.23 Geobacillus stearothermophilus
-
-
-
1.1.1.23 Sporosarcina psychrophila
-
-
-
1.1.1.23 [Bacillus] caldolyticus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.23 ammonium sulfate precipitation, heating, affinity chromatography, preparative gel Geobacillus stearothermophilus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.23 3.11
-
-
 Sporosarcina psychrophila
1.1.1.23 3.56
-
-
 Bacillus subtilis
1.1.1.23 3.86
-
-
 Geobacillus stearothermophilus
1.1.1.23 3.89
-
-
 Bacillus subtilis
1.1.1.23 3.89
-
-
 [Bacillus] caldolyticus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Bacillus subtilis L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Geobacillus stearothermophilus L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O
-
 [Bacillus] caldolyticus L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Sporosarcina psychrophila L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Bacillus subtilis L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Geobacillus stearothermophilus L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate [Bacillus] caldolyticus L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Sporosarcina psychrophila L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Bacillus subtilis HT1 L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Bacillus subtilis HT1 L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Bacillus subtilis L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Geobacillus stearothermophilus L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 [Bacillus] caldolyticus L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Sporosarcina psychrophila L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Bacillus subtilis HT1 L-histidine + 2 NADH + 2 H+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.23 25
-
-
 Sporosarcina psychrophila
1.1.1.23 41
-
-
 Bacillus subtilis
1.1.1.23 74
-
-
 Geobacillus stearothermophilus
1.1.1.23 87
-
-
 [Bacillus] caldolyticus
1.1.1.23 92
-
-
 Bacillus subtilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.23 9.6
-
-
 Bacillus subtilis
1.1.1.23 9.6
-
-
 Geobacillus stearothermophilus
1.1.1.23 9.6
-
-
 [Bacillus] caldolyticus
1.1.1.23 9.6
-
-
 Sporosarcina psychrophila

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.23 NAD+
-
 Bacillus subtilis
1.1.1.23 NAD+
-
 Geobacillus stearothermophilus
1.1.1.23 NAD+
-
 [Bacillus] caldolyticus
1.1.1.23 NAD+
-
 Sporosarcina psychrophila