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Literature summary extracted from

  • Molowa, D.T.; Shayne, A.G.; Guzelian, P.S.
    Purification and characterization of chlordecone reductase from human liver (1986), J. Biol. Chem., 261, 12624-12627.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.225 Cu2+ slight inhibition Homo sapiens
1.1.1.225 Cu2+ slight inhibition Meriones unguiculatus
1.1.1.225 Ethacrynic acid
-
 Homo sapiens
1.1.1.225 Ethacrynic acid
-
 Meriones unguiculatus
1.1.1.225 Hg2+ slight inhibition Homo sapiens
1.1.1.225 Hg2+ slight inhibition Meriones unguiculatus
1.1.1.225 indomethacin
-
 Homo sapiens
1.1.1.225 indomethacin
-
 Meriones unguiculatus
1.1.1.225 additional information not inhibited by phenobarbital Homo sapiens
1.1.1.225 additional information not inhibited by phenobarbital Meriones unguiculatus
1.1.1.225 p-chloromercuribenzoate
-
 Homo sapiens
1.1.1.225 p-chloromercuribenzoate
-
 Meriones unguiculatus
1.1.1.225 quercetin
-
 Homo sapiens
1.1.1.225 quercetin
-
 Meriones unguiculatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.225 0.003
-
 Chlordecone
-
 Homo sapiens
1.1.1.225 0.003
-
 Chlordecone
-
 Meriones unguiculatus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.225 cytoplasm
-
 Homo sapiens 5737
-
1.1.1.225 cytoplasm
-
 Oryctolagus cuniculus 5737
-
1.1.1.225 cytoplasm
-
 Meriones unguiculatus 5737
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.225 Homo sapiens
-
-
-
1.1.1.225 Meriones unguiculatus
-
-
-
1.1.1.225 no activity in Mesocricetus auratus
-
-
-
1.1.1.225 no activity in Mus musculus
-
-
-
1.1.1.225 no activity in Rattus norvegicus
-
-
-
1.1.1.225 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.225
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.225 liver
-
 Homo sapiens
-
1.1.1.225 liver
-
 Oryctolagus cuniculus
-
1.1.1.225 liver
-
 Meriones unguiculatus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.225 0.008
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.1.1.225 -70°C, 50% glycerol Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.225 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
-
 Homo sapiens chlordecone alcohol + NADP+
-
 ?
1.1.1.225 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
-
 Oryctolagus cuniculus chlordecone alcohol + NADP+
-
 ?
1.1.1.225 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
-
 Meriones unguiculatus chlordecone alcohol + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.225 7.5
-
 2 optima: pH 7.5 and 9.0 Homo sapiens
1.1.1.225 9
-
 2 optima: pH 7.5 and 9.0 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.225 additional information no activity with NADH Homo sapiens
1.1.1.225 NADPH
-
 Homo sapiens
1.1.1.225 NADPH
-
 Oryctolagus cuniculus
1.1.1.225 NADPH
-
 Meriones unguiculatus