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Literature summary extracted from

  • Molowa, D.T.; Wrighton, S.A.; Blanke, R.V.; Guzelian, P.S.
    Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man (1986), J. Toxicol. Environ. Health, 17, 375-384.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.225 Ethacrynic acid
-
 Homo sapiens
1.1.1.225 Ethacrynic acid
-
 Meriones unguiculatus
1.1.1.225 indomethacin
-
 Homo sapiens
1.1.1.225 indomethacin
-
 Meriones unguiculatus
1.1.1.225 additional information not inhibited by phenobarbital Homo sapiens
1.1.1.225 additional information not inhibited by phenobarbital Meriones unguiculatus
1.1.1.225 p-chloromercuribenzoate
-
 Homo sapiens
1.1.1.225 p-chloromercuribenzoate strong inhibition Meriones unguiculatus
1.1.1.225 quercetin
-
 Homo sapiens
1.1.1.225 quercetin weak inhibition Meriones unguiculatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.225 0.0026
-
 Chlordecone
-
 Meriones unguiculatus
1.1.1.225 0.005
-
 NADPH
-
 Meriones unguiculatus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.225 cytoplasm
-
 Homo sapiens 5737
-
1.1.1.225 cytoplasm
-
 Oryctolagus cuniculus 5737
-
1.1.1.225 cytoplasm
-
 Meriones unguiculatus 5737
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.225 Homo sapiens
-
-
-
1.1.1.225 Meriones unguiculatus
-
-
-
1.1.1.225 no activity in Cavia porcellus
-
-
-
1.1.1.225 no activity in Mesocricetus auratus
-
-
-
1.1.1.225 no activity in Mus musculus
-
-
-
1.1.1.225 no activity in Rattus norvegicus
-
-
-
1.1.1.225 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.225 brain
-
 Meriones unguiculatus
-
1.1.1.225 heart
-
 Meriones unguiculatus
-
1.1.1.225 intestine
-
 Meriones unguiculatus
-
1.1.1.225 kidney
-
 Meriones unguiculatus
-
1.1.1.225 liver
-
 Homo sapiens
-
1.1.1.225 liver
-
 Oryctolagus cuniculus
-
1.1.1.225 liver
-
 Meriones unguiculatus
-
1.1.1.225 lung
-
 Meriones unguiculatus
-
1.1.1.225 additional information found in all tissues, highest activity in liver, intestine and kidney Meriones unguiculatus
-
1.1.1.225 spleen
-
 Meriones unguiculatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.225 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH organochlorine pesticide, trivial names: chlordecone or kepone Homo sapiens chlordecone alcohol + NADP+
-
 ?
1.1.1.225 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH organochlorine pesticide, trivial names: chlordecone or kepone Oryctolagus cuniculus chlordecone alcohol + NADP+
-
 ?
1.1.1.225 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH organochlorine pesticide, trivial names: chlordecone or kepone Meriones unguiculatus chlordecone alcohol + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.225 6.5
-
-
 Meriones unguiculatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.225 NADPH
-
 Homo sapiens
1.1.1.225 NADPH
-
 Oryctolagus cuniculus
1.1.1.225 NADPH
-
 Meriones unguiculatus