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Literature summary extracted from

  • Strominger, J.L.; Maxwell, E.S.; Axelrod, J.; Kalckar, H.M.
    Enzymatic formation of uridine diphosphoglucuronic acid (1957), J. Biol. Chem., 224, 79-90.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.22 Deamino adenine dinucleotide can replace NAD+ Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.22 UDPglucose + NAD+ + H2O Bos taurus
-
 UDPglucuronate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.22 Bos taurus
-
 calf
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.22 calf Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.22 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.22 additional information
-
-
 Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.1.1.22 -10°C, little loss of activity after several weeks Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.22 additional information cosubstrates which can replace NAD+: 3-acetylpyridine adenine dinucleotide Bos taurus ?
-
 ?
1.1.1.22 additional information no reaction with NADP+ Bos taurus ?
-
 ?
1.1.1.22 additional information no activity with glucose Bos taurus ?
-
 ?
1.1.1.22 additional information deamino adenine dinucleotide Bos taurus ?
-
 ?
1.1.1.22 additional information no activity with uridine diphosphoacetylgalactosamine Bos taurus ?
-
 ?
1.1.1.22 additional information no activity with ethyl alcohol Bos taurus ?
-
 ?
1.1.1.22 additional information no activity with alpha-D-glucose-1-phosphate Bos taurus ?
-
 ?
1.1.1.22 additional information no activity with guanosine diphosphomannose Bos taurus ?
-
 ?
1.1.1.22 additional information no activity with uridine diphosphoacetylglucosamine Bos taurus ?
-
 ?
1.1.1.22 UDP-glucose + 2 NAD+ + H2O reversal of reaction cannot be demonstrated Bos taurus UDP-glucuronate + 2 NADH + 2 H+
-
 ?
1.1.1.22 UDP-glucose + 3-acetylpyridine adenine dinucleotide + H2O
-
 Bos taurus UDP-glucuronate + ?
-
 ?
1.1.1.22 UDP-glucose + deamino adenine dinucleotide + H2O
-
 Bos taurus UDP-glucuronate + ?
-
 ?
1.1.1.22 UDPglucose + NAD+ + H2O
-
 Bos taurus UDPglucuronate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.22 8.7
-
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.22 7.8 9.4 at pH 7.8 and 9.4 about 50% of activity maximum Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.22 3-acetylpyridine adenine dinucleotide can replace NAD+ Bos taurus