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Literature summary extracted from
- The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria (1982), Biochim. Biophys. Acta, 713, 270-279.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.211 | defatted serum albumin | only with long-chain e.g. C16 3-ketoacyl-CoA, in concentrations lower than 0.6 mg/ml | Rattus norvegicus | |
| 1.1.1.211 | defatted serum albumin | only with long-chain e.g. C16 3-ketoacyl-CoA, in concentrations lower than 0.6 mg/ml | Oryctolagus cuniculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.211 | defatted serum albumin | only with long-chain e.g. C16 3-ketoacyl-CoA, in concentrations higher than 0.6 mg/ml | Oryctolagus cuniculus | |
| 1.1.1.211 | defatted serum albumin | only with long-chain e.g. C16 3-ketoacyl-CoA, in concentrations higher than 0.6 mg/ml | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.35 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
| 1.1.1.211 | mitochondrial inner membrane | - |
Rattus norvegicus | 5743 | - |
| 1.1.1.211 | mitochondrial inner membrane | - |
Oryctolagus cuniculus | 5743 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.35 | 70000 | - |
gel filtration | Rattus norvegicus |
| 1.1.1.211 | 186000 | - |
liver, gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.35 | (S)-3-hydroxybutyryl-CoA + NAD+ | Rattus norvegicus | - |
acetoacetyl-CoA + NADH | - |
r |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.35 | Rattus norvegicus | - |
- |
- |
| 1.1.1.211 | Oryctolagus cuniculus | - |
neonatal | - |
| 1.1.1.211 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.35 | brain | - |
Rattus norvegicus | - |
| 1.1.1.35 | heart | - |
Rattus norvegicus | - |
| 1.1.1.35 | kidney | - |
Rattus norvegicus | - |
| 1.1.1.35 | liver | - |
Rattus norvegicus | - |
| 1.1.1.211 | brown adipose tissue | - |
Oryctolagus cuniculus | - |
| 1.1.1.211 | heart | - |
Rattus norvegicus | - |
| 1.1.1.211 | kidney | - |
Rattus norvegicus | - |
| 1.1.1.211 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.35 | 0.033 | - |
enzyme activity in brain mitochondria, substrate acetoacetyl-CoA | Rattus norvegicus |
| 1.1.1.35 | 0.48 | - |
enzyme activity in inner membrane of liver mitochondria, substrate acetoacetyl-CoA | Rattus norvegicus |
| 1.1.1.35 | 0.78 | - |
enzyme activity in kidney mitochondria, substrate acetoacetyl-CoA | Rattus norvegicus |
| 1.1.1.35 | 1.5 | - |
enzyme activity in heart mitochondria, substrate acetoacetyl-CoA | Rattus norvegicus |
| 1.1.1.35 | 1.67 | - |
enzyme activity in liver mitochondria, substrate acetoacetyl-CoA | Rattus norvegicus |
| 1.1.1.35 | 2.3 | - |
enzyme activity in liver mitoplasts, substrate acetoacetyl-CoA | Rattus norvegicus |
| 1.1.1.35 | 3.4 | - |
enzyme activity in matrix of liver mitochondria, substrate acetoacetyl-CoA | Rattus norvegicus |
| 1.1.1.211 | additional information | - |
it is specific for long chain substrate and has maximum activity with 3-ketohexadecanoyl-CoA | Rattus norvegicus |
| 1.1.1.211 | additional information | - |
it is specific for long chain substrate and has maximum activity with 3-ketohexadecanoyl-CoA | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.35 | (S)-3-hydroxybutyryl-CoA + NAD+ | - |
Rattus norvegicus | acetoacetyl-CoA + NADH | - |
r | |
| 1.1.1.35 | (S)-3-hydroxybutyryl-CoA + NAD+ | highest activity with acetoacetyl-CoA, significant activity with increasing chain length up to C16 | Rattus norvegicus | acetoacetyl-CoA + NADH | - |
r | |
| 1.1.1.211 | 3-ketohexadecanoyl-CoA + NADH | - |
Rattus norvegicus | 3-hydroxyhexadecanoyl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | 3-ketohexadecanoyl-CoA + NADH | - |
Oryctolagus cuniculus | 3-hydroxyhexadecanoyl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | 3-ketohexanoyl-CoA + NADH | - |
Rattus norvegicus | 3-hydroxyhexanoyl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | 3-ketohexanoyl-CoA + NADH | - |
Oryctolagus cuniculus | 3-hydroxyhexanoyl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | 3-oxodecanoyl-CoA + NADH | - |
Rattus norvegicus | 3-hydroxydecanoyl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | 3-oxodecanoyl-CoA + NADH | - |
Oryctolagus cuniculus | 3-hydroxydecanoyl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | acetoacetyl-CoA + NADH + H+ | - |
Rattus norvegicus | 3-hydroxybutyryl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | acetoacetyl-CoA + NADH + H+ | - |
Oryctolagus cuniculus | 3-hydroxybutyryl-CoA + NAD+ | - |
? | |
| 1.1.1.211 | additional information | has also enoyl-CoA-hydratase activity | Rattus norvegicus | additional information | - |
? | |
| 1.1.1.211 | additional information | has also enoyl-CoA-hydratase activity | Oryctolagus cuniculus | additional information | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.35 | NAD+ | - |
Rattus norvegicus | |
| 1.1.1.211 | NAD+ | - |
Rattus norvegicus | |
| 1.1.1.211 | NAD+ | - |
Oryctolagus cuniculus | |
| 1.1.1.211 | NADH | - |
Rattus norvegicus | |
| 1.1.1.211 | NADH | - |
Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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